Author(s): Mukthinuthalapati Mathrusri Annapurna, Gunnam Ravi Teja, Ponnekanti Krishna Phani Sri, Boni Chaitanya

Email(s): mathrusri2000@yahoo.com

DOI: 10.5958/0974-360X.2017.00180.9   

Address: Mukthinuthalapati Mathrusri Annapurna*, Gunnam Ravi Teja, Ponnekanti Krishna Phani Sri, Boni Chaitanya
Department of Pharmaceutical Analysis & Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam-530045, India
*Corresponding Author

Published In:   Volume - 10,      Issue - 4,     Year - 2017


ABSTRACT:
Eight simple spectrophotometric techniques have been proposed for the determination of Raltegravir in pharmaceutical preparations. Three zero order (D0), three first order derivative (D!) and two difference spectrophotometric methods have been developed in for the determination of Raltegravir in borate buffer (pH 9), hydrochloric acid and sodium acetate buffer solutions. Linearity has been followed over the concentration range 1-150, 10-150 and 10-150 µg/mL in all the buffers in zero order, first order derivative and difference spectroscopy respectively. All the methods were validated and can be very successfully applied for the determination of Raltegravir in pharmaceutical formulations.


Cite this article:
Mukthinuthalapati Mathrusri Annapurna, Gunnam Ravi Teja, Ponnekanti Krishna Phani Sri, Boni Chaitanya. Determination of Raltegravir by derivative and difference spectrophotometric techniques in film coated tablets. Research J. Pharm. and Tech. 2017; 10(4): 991-997. doi: 10.5958/0974-360X.2017.00180.9


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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