Author(s): Nikita S. Malekar, Sheetal B. Gondkar, Bhushan A. Bhairav, Pinak S. Paralkar, Ravindra B. Saudagar

Email(s): nikitamalekarresearch @gmail.com

DOI: 10.5958/0974-360X.2017.00178.0   

Address: Nikita S. Malekar1*, Sheetal B. Gondkar1, Bhushan A. Bhairav1, Pinak S. Paralkar2, Ravindra B. Saudagar 3
1Department of Quality Assurance Techniques, KCT’S, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik 422213, Maharashtra , India
2Department of Pharmaceutics , KCT’S, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik 422213, Maharashtra, India
3Department of Pharmaceutical Chemistry, KCT’S, Ravindra Gambhirrao College of Pharmacy, Anjaneri, Nashik 422213, Maharashtra, India
*Corresponding Author

Published In:   Volume - 10,      Issue - 4,     Year - 2017


ABSTRACT:
Development of pH sensitive Naratriptan Hydrochloride in-situ nasal gel was aimed to improve absorption. In the present research work mixture of Carbopol-934 and Xanthan Gum were used to benefit pH sensitive gelation property. Different formulation were prepared by different concentrations of Carbopol-934 and Xanthan Gum .In this formulation the release profile depend on the concentration of Carbopol-934 and Xanthan Gum. These formulations were evaluated for parameters like pH, drug content, viscosity, mucoadhesive strength, gel strength, in-vitro drug release, and drug and excipients compatability. A 32 factorial design was applied to see the effect of various Carbopol-934 (X1) and Xanthan gum (X2) on the various models to a certain kinetic of drug release. Regression analysis and analysis of variance were performed for dependent variables. The study indicates that the formulation was effective in providing in-vitro release of drug and the mucoadhesive formulation. The objective of this study was to formulate a intranasal gel for drug targeting directly to brain via olfactory lobe pathway.


Cite this article:
Nikita S. Malekar, Sheetal B. Gondkar, Bhushan A. Bhairav, Pinak S. Paralkar, Ravindra B. Saudagar. Development of Naratriptan Hydrochloride In-Situ Nasal Gel. Research J. Pharm. and Tech. 2017; 10(4): 979-985. doi: 10.5958/0974-360X.2017.00178.0


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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