Author(s): Amir Alhaj Sakur*, Shaza Affas

Email(s): profsakur@gmail.com , shazaaffas@gmail.com

DOI: 10.5958/0974-360X.2017.00214.1   

Address: Amir Alhaj Sakur*, Shaza Affas
Analytical and Food Chemistry Department, Faculty of Pharmacy, University of Aleppo, Syria
*Corresponding Author

Published In:   Volume - 10,      Issue - 4,     Year - 2017


ABSTRACT:
Objective: Simple, sensitive and free- extraction spectrophotometric methods have been developed for the determination of Sildenafil citrate (SIL) both in pure and in pharmaceutical forms. Methods: Two spectrophotometric methods are based on the formation of yellow colored ion-pair complexes between the studied drug and two sulphonphthalein acid dyes, bromocresol green (BCG)(method A) and bromothymol blue (BTB) (method B) with absorption maxima at 414 and 409 nm, respectively. Results: The effects of analytical parameters on the reported systems were investigated. The complexation reactions were extremely rapid at room temperature and t¬he absorption values remain unchanged up to 24h. Various analytical parameters have been evaluated and the results have been validated by statistical. Beer’s law was obeyed in the concentration ranges of (1.33 – 50) µg/ml for method A and (0.8 -27) µg/ml for method B, the limits of detection were 0.093 and 0.059 µg/ml and the molar absorptivity coefficients were 2.28×104 and 3.05 ×104 L .moL-1.cm-1 for method A and B respectively. Conclusion: The proposed methods were successfully applied to the analysis of commercial tablets containing the drugs. Two methods were free-extractive, rapid, and have high sensitivity comparing with other previous direct spectrophotometric methods. Interferences of the other ingredients and excipients were not observed.


Cite this article:
Amir Alhaj Sakur*, Shaza Affas. Direct Spectrophotometric Determination of Sildenafil Citrate in Pharmaceutical Preparations Via Complex Formation with Two sulphonphthalein acid dyes. Research J. Pharm. and Tech. 2017; 10(4): 1191-1196. doi: 10.5958/0974-360X.2017.00214.1


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DOI: 10.5958/0974-360X 

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