Author(s): Mukthinuthalapati Mathrusri Annapurna, Vellanki S. V. Sevyatha, Malineni Sushmitha

Email(s): mathrusri2000@yahoo.com

DOI: 10.5958/0974-360X.2017.00225.6   

Address: Mukthinuthalapati Mathrusri Annapurna*, Vellanki S. V. Sevyatha, Malineni Sushmitha
Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam-530045, India
*Corresponding Author

Published In:   Volume - 10,      Issue - 4,     Year - 2017


ABSTRACT:
Four simple spectrophotometric methods have been developed for the simultaneous determination of Fluorometholone and Ketorolac tromethamine in ophthalmic preparations. Simultaneous equation method, absorbance ratio method (Q – Analysis), first derivative method and multicomponent mode of analytical techniques were selected for the determination of Fluorometholone and Ketorolac tromethamine in phosphate buffer (pH 2.0) solution. Fluorometholone and Ketorolac tromethamine has followed linearity over the concentration range 0.1-20 µg/mL and 1-20 µg/mL respectively. The methods were validated and applied for the simultaneous determination of Fluorometholone and Ketorolac tromethamine in the available pharmaceutical formulations i.e. eye drops.


Cite this article:
Mukthinuthalapati Mathrusri Annapurna, Vellanki S. V. Sevyatha, Malineni Sushmitha. Simultaneous determination of Ketorolac tromethamine and Fluorometholone in Eye drops by spectrophotometry. Research J. Pharm. and Tech. 2017; 10(4): 1179-1183. doi: 10.5958/0974-360X.2017.00225.6

Cite(Electronic):
Mukthinuthalapati Mathrusri Annapurna, Vellanki S. V. Sevyatha, Malineni Sushmitha. Simultaneous determination of Ketorolac tromethamine and Fluorometholone in Eye drops by spectrophotometry. Research J. Pharm. and Tech. 2017; 10(4): 1179-1183. doi: 10.5958/0974-360X.2017.00225.6   Available on: https://rjptonline.org/AbstractView.aspx?PID=2017-10-4-40


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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