Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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New validated RP-HPLC method for the determination of Vilazodone hydrochloride – A serotonergic Anti-depressant

Author(s): Mukthinuthalapati Mathrusri Annapurna, Kunala Anusha, Afreen Shahena Sharief, Varanasi Sindhuri

Email(s): mathrusri2000@yahoo.com

DOI: 10.5958/0974-360X.2017.00195.0   

Address: Mukthinuthalapati Mathrusri Annapurna*, Kunala Anusha, Afreen Shahena Sharief, Varanasi Sindhuri
Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam-530045, India
*Corresponding Author

Published In:   Volume - 10,      Issue - 4,     Year - 2017

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ABSTRACT:
A new simple liquid chromatographic method has been established for the determination of Vilazodone hydrochloride in pharmaceutical formulations. Vilazodone hydrochloride is a strong dopamine antagonist. Vilazodone hydrochloride was approved by the FDA for use in the United States to treat major depressive disorder in January 21, 2011. A mobile phase containing0.1M Ammonium formate: Methanol (20:80, v/v) with flow rate 0.7 mL/min was used for the present chromatographic study(UV detection 241 nm). Linearity was followed over the concentration range 0.1-120 µg/mL. Forced degradation studies were performed by exposing the drug Vilazodone hydrochloride to alkaline, acidic, and oxidation stress degradations. The method was validated as per ICH guidelines (ICH Guidelines 2005).


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Cite this article:
Mukthinuthalapati Mathrusri Annapurna, Kunala Anusha, Afreen Shahena Sharief, Varanasi Sindhuri. New validated RP-HPLC method for the determination of Vilazodone hydrochloride – A serotonergic Anti-depressant. Research J. Pharm. and Tech. 2017; 10(4): 1077-1080. doi: 10.5958/0974-360X.2017.00195.0


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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