Author(s):
K. Ishwar Bhat, Abhishek Kumar
Email(s):
abhi12bunty@gmail.com
DOI:
10.5958/0974-360X.2017.00190.1 
Address:
K. Ishwar Bhat1, Abhishek Kumar2
1Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka
2Assistant Professor, Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences Paneer, Deralakatte, Mangalore 575018, Karnataka, India
*Corresponding Author
Published In:
Volume - 10,
Issue - 4,
Year - 2017
ABSTRACT:
A series of novel 4-(4-nitrophenyl)-6-phenyl substituted pyrimidine-2-thiol (PM1-PM6) have been synthesized by refluxing 1-(4-nitrophenyl)-3-phenyl substituted prop-2-en-1-one in presence of thiourea and glacial acetic acid. 1-(4-nitrophenyl)-3-phenyl substituted prop-2-en-1-one were prepared by condensing 4-nitroacetophenone with substituted benzaldehydes in presence of 20% NaOH as base. The structures of newly synthesized compounds were characterized by IR, 1H NMR and mass spectroscopic studies. Newly synthesized compounds were screened for their anti-inflammatory and cytotoxic studies. Few of the compounds exhibited excellent anti-inflammatory compared to the standard drug diclofenac sodium. Some compounds have shown moderate cytotoxic activities.
Cite this article:
K. Ishwar Bhat, Abhishek Kumar. Synthesis, Biological and Pharmacological Screening of Novel Pyrimidine Derivatives. Research J. Pharm. and Tech. 2017; 10(4): 1049-1052. doi: 10.5958/0974-360X.2017.00190.1
Cite(Electronic):
K. Ishwar Bhat, Abhishek Kumar. Synthesis, Biological and Pharmacological Screening of Novel Pyrimidine Derivatives. Research J. Pharm. and Tech. 2017; 10(4): 1049-1052. doi: 10.5958/0974-360X.2017.00190.1 Available on: https://rjptonline.org/AbstractView.aspx?PID=2017-10-4-17