Author(s): K. Ishwar Bhat, Abhishek Kumar

Email(s): abhi12bunty@gmail.com

DOI: 10.5958/0974-360X.2017.00190.1   

Address: K. Ishwar Bhat1, Abhishek Kumar2
1Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka
2Assistant Professor, Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences Paneer, Deralakatte, Mangalore 575018, Karnataka, India
*Corresponding Author

Published In:   Volume - 10,      Issue - 4,     Year - 2017


ABSTRACT:
A series of novel 4-(4-nitrophenyl)-6-phenyl substituted pyrimidine-2-thiol (PM1-PM6) have been synthesized by refluxing 1-(4-nitrophenyl)-3-phenyl substituted prop-2-en-1-one in presence of thiourea and glacial acetic acid. 1-(4-nitrophenyl)-3-phenyl substituted prop-2-en-1-one were prepared by condensing 4-nitroacetophenone with substituted benzaldehydes in presence of 20% NaOH as base. The structures of newly synthesized compounds were characterized by IR, 1H NMR and mass spectroscopic studies. Newly synthesized compounds were screened for their anti-inflammatory and cytotoxic studies. Few of the compounds exhibited excellent anti-inflammatory compared to the standard drug diclofenac sodium. Some compounds have shown moderate cytotoxic activities.


Cite this article:
K. Ishwar Bhat, Abhishek Kumar. Synthesis, Biological and Pharmacological Screening of Novel Pyrimidine Derivatives. Research J. Pharm. and Tech. 2017; 10(4): 1049-1052. doi: 10.5958/0974-360X.2017.00190.1


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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