Author(s): Farhatjahan I. Shaikh, Meenakshi B. Patel, Naazneen I. Surti, Vandana B. Patel

Email(s): vbpatel04@yahoo.com

DOI: 10.5958/0974-360X.2017.00189.5   

Address: Farhatjahan I. Shaikh, Meenakshi B. Patel, Naazneen I. Surti, Vandana B. Patel*
Babaria Institute of Pharmacy, BITS Educational Campus, Varnama, Vadodara, Gujarat, India
*Corresponding Author

Published In:   Volume - 10,      Issue - 4,     Year - 2017


ABSTRACT:
Lercanidipine Hydrochloride (LER) is widely used antihypertensive drug belonging to BCS Class II and showing pH dependent solubility. The bioavailability of LER is limited because of its poor water solubility. Inclusion complexes of LER were prepared with ß-Cyclodextrin (ßCD) using kneading and freeze drying techniques in different molar ratios to enhance solubility of LER and improve dissolution characteristic of the same. The phase solubility study was performed to study interaction between ßCD and LER in solution. Phase solubility graph showed a linear diagram classified as AL type. From the slope of phase solubility diagram, stability constant K was calculated and was found to be 428.28 M-1 suggesting strong interaction between guest and host molecule. Water solubility and dissolution was significantly increased when inclusion complex was prepared by freeze drying technique in 1:1.5 Molar ratio. Further formation of inclusion complex was confirmed by Fourier transformation-infrared (FT-IR), powder X-ray diffractometry (PXRD) and 1H Nuclear Magnetic Resonance (NMR). Solid state characterization suggested strong interaction of LER in ßCD forming inclusion complex. From the result of XRD, it was confirmed that the decrease in crystal structure of LER takes place upon formation of inclusion complex. Freeze dried inclusion complex of LER with ßCD in 1:1.5 molar ratio showed 5.4 fold increase in solubility of LER along with 80 % release in 60 minutes. The study concludes that Cyclodextrin complexation can influence solubility and dissolution of LER positively and thus can be used to design novel formulation of LER with improved dissolution and bioavailability.


Cite this article:
Farhatjahan I. Shaikh, Meenakshi B. Patel, Naazneen I. Surti, Vandana B. Patel. Preparation and Characterization of Lercanidipine Hydrochloride Inclusion complex with β-cyclodextrin and effect of Complexation on Solubility and Dissolution. Research J. Pharm. and Tech. 2017; 10(4): 1041-1048. doi: 10.5958/0974-360X.2017.00189.5


Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Ahmed Hilal Sheriff, Preetham Prasad Nittla

DOI: 10.5958/0974-360X.2019.00968.5         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Leelavathi D Acharya, N R Rau, N Udupa, Surulivel Rajan M, Vijayanarayana K

DOI: 10.5958/0974-360X.2016.00162.1         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Vishal Vilas Shah, Nutan Dhanpal Shah, Prasad Vasantrao Patrekar

DOI: Not Available         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Malarkodi Velraj, P. Jasmine Shiney, Biplab Paul, Rashmi. S, Nivethitha

DOI: 10.5958/0974-360X.2017.00006.3         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags