Author(s): Narayana Charyulu R, Sandeep DS, Abhishiktha Alva, Divya Rao, Prashant Nayak, Jobin Jose, Bahrath Raj KC

Email(s): narayana@nitte.edu.in

DOI: 10.5958/0974-360X.2017.00162.7   

Address: Narayana Charyulu R1*, Sandeep DS1, Abhishiktha Alva1, Divya Rao1, Prashant Nayak1, Jobin Jose1, Bahrath Raj KC2
1Department of Pharmaceutics, NGSM Institute of Pharmaceutical sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, India.
2Department of Pharmacology, NGSM Institute of Pharmaceutical sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 3,     Year - 2017


ABSTRACT:
Fungal infections affecting nails are commonly seen around the world. The effectiveness of topical therapies is limited by minimal drug permeability through the nail plate. Nail permeability is however quite low and limits topical therapy to early/mild disease states such as onychomycosis (fungal infections of the nail). The current research aims at ungual drug delivery system as an effective treatment in nail infections. The formulations of nail lacquer were made with Amorolfine as antifungal agent using different concentration of polymer Eudragit RL 100 (ERL 100). Among 6 formulations, formulation F5 and F6 showed very good physical characteristics like viscosity, water resistance, stability, drying time, smoothness as compared to other formulations. The zone of inhibition of antifungal activity showed desired results (F5 and F6).


Cite this article:
Narayana Charyulu R, Sandeep DS, Abhishiktha Alva, Divya Rao, Prashant Nayak, Jobin Jose, Bahrath Raj KC. Formulation and Evaluation Ungual Drug Delivery System of Antifungal Agent for Nail Disorders. Research J. Pharm. and Tech. 2017; 10(3): 869-872. doi: 10.5958/0974-360X.2017.00162.7


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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