Author(s): Minakshi Shroff, S. J. Daharwal, Yashwant Swarnakar

Email(s): mahishroff@gmail.com

DOI: 10.5958/0974-360X.2017.00126.3   

Address: Minakshi Shroff1, Dr. S. J. Daharwal2, Yashwant Swarnakar3
1Deptt. of Pharmaceutical Sciences, Uttarakhand Technical University, Deheradun. (U.K.)
2University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.)
3Shri Shankaracharya Institute of Pharmaceutical Sciences, Bhilai (C.G.)
*Corresponding Author

Published In:   Volume - 10,      Issue - 3,     Year - 2017


ABSTRACT:
In the present work, ten novel 3-(4,5-dihydro-3-(naphthalen-1-yl)- N1-substituted -pyrazol-5-yl)-1H-indole [1,1a,1b.1e,2] and 3-(4,5-dihydro-3-(pyridin-3-yl)-N1-substituted-pyrazol-5-yl)-1H-indole [5,5a,5b,5e.6] were synthesized by condensation between substituted pyrazoline and substituted hydrazine in the presence of glacial acetic acid. The synthesized compounds were evaluated for their anti-inflammatory activity using carrageenan-induced paw oedema method and compared to the well known NSAID indomethacin as a standard drug. The entire synthesized compounds were characterized by elemental analysis, IR, 1H NMR and mass spectroscopy.


Cite this article:
Minakshi Shroff, S. J. Daharwal, Yashwant Swarnakar. Synthesis and Characterization of Indolyl-pyrazoline and their Evaluation of anti-inflammatory Activity. Research J. Pharm. and Tech. 2017; 10(3): 677-682. doi: 10.5958/0974-360X.2017.00126.3


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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