ABSTRACT:
Granulation refers to the act or process in which primary powder particles are made to adhere to form larger, multiparticle entities called granules. It is the process of collecting particles together by creating bonds between them. Bonds are formed by compression or by using a binding agent. Granulation is extensively used in the manufacturing of tablets and pellets. Pharmaceutical granules typically have a size range between 0.2 and 4.0 mm, depending on their subsequent use. After granulation the granules will either be packed or they may be mixed with other excipients prior to tablet compaction or capsule filling. Granules are produced to enhance the uniformity of the API in the final product, to increase the density of the blend so that it occupies less volume per unit weight for better storage and shipment, to facilitate metering or volumetric dispensing, to reduce dust during granulation process to reduce toxic exposure and process-related hazards, and to improve the appearance of the production. This review focuses on the recent progress in the granulation techniques and technologies. This review gives an overview of these with a short description about each development along with its significance and limitations.