Author(s): Mohamed Mustafa, S. Amuthalakshmi, C.N. Nalini

Email(s): amuthaaris@gmail.com

DOI: 10.5958/0974-360X.2017.00111.1   

Address: Mohamed Mustafa, S. Amuthalakshmi*, C.N. Nalini
Department of pharmaceutical analysis, C.L. Baid Metha College of Pharmacy, Thorapakkam, Chennai-600097.
*Corresponding Author

Published In:   Volume - 10,      Issue - 2,     Year - 2017


ABSTRACT:
A new simple, rapid and sensitive Gradient Ultra Performance Liquid Chromatography (UPLC) method has been developed for the determination of Fexofenadine HCl and Montelukast Sodium. The method employs Thermo Scientific UPLC system on Waters (symmetry) (c18 1.8 micron 4.6 x 50mm) column. Best chromatographic separation was achieved by using acetonitrile: 20 mM potassium dihydrogen phosphate 80:30 (v/v) adjusted to pH 5.5 using orthophosphoric acid as mobile phase at a flow rate of 1 ml/min and detection at 230 nm. Separation was completed within 10 min. The retention time of Fexofenadine HCl and Montelukast Sodium was found to be 1.022 and 3.281. The proposed method was found to have linearity in concentration range of 80-120 µg/ml and 96-144 µg/m. The developed method has been statistically validated and was found to be simple, precise, reproducible and accurate. The developed and validated method was successfully used for the quantitative analysis of commercially available dosage form.


Cite this article:
Mohamed Mustafa, S. Amuthalakshmi, C.N. Nalini. Simultaneous UPLC Estimation of Fexofenadine HCl and Montelukast Sodium Tablets. Research J. Pharm. and Tech. 2017; 10(2): 557-561. doi: 10.5958/0974-360X.2017.00111.1


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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