Author(s): Ashok Hajare, Kaustubh Joshi, Trupti Powar

Email(s): ashok.hajare@bharatividyapeeth.edu

DOI: 10.5958/0974-360X.2017.00826.5   

Address: Ashok Hajare*, Kaustubh Joshi, Trupti Powar
Department of Pharmaceutical Technology, Bharati Vidyapeeth College of Pharmacy Kolhapur, Maharashtra, 416 013, India
*Corresponding Author

Published In:   Volume - 10,      Issue - 12,     Year - 2017


ABSTRACT:
The objective of present study was preparing a simple, effective solid dosage form by using Lyopan® technology for easy swallow and quick release of drug from tablets during emergency.Present study aims to enhance the aqueous solubility and dissolution of amlodipine by developing freeze dried tablets. Tablets were prepared by dispersing the drug in an aqueous solution of highly water-soluble carrier materials consisting of gelatine and mannitol. The mixture is poured in to the pockets of blister packs and subjected to lyophilization. The bulking agent and binder were optimized by processing with various concentrations of both, and best batch was selected. The prepared formulations were characterized with various analytical techniques like FTIR, XRD, SEM, andDSC. The studies proved the existence of amorphous nature of drug accounting for high solubility and disintegration, Moisture content and disintegration time were used in determining stability of the material. The dosage form prepared was found to sustain handling to a good extent, despite its characteristic brittleness.


Cite this article:
Ashok Hajare, Kaustubh Joshi, Trupti Powar. Fast Dissolving Tablets of Amlodipine Besilate by Lyopan® Technique. Research J. Pharm. and Tech 2017; 10(12): 4474-4482. doi: 10.5958/0974-360X.2017.00826.5


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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