Author(s): I. Arjun Rao, Moumita Sinha, Manju Sahu, Bharati Ahirwar

Email(s): moumita4n6@gmail.com

DOI: 10.5958/0974-360X.2017.00819.8   

Address: I. Arjun Rao1, Moumita Sinha1*, Manju Sahu1 , Bharati Ahirwar2
1Assistant Professor (Ad-hoc), Department of Forensic Science, Guru Ghasidas University, Bilaspur (C.G.)- 495009
2Head, Department of Forensic Science and Associate Professor, SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur (C.G.)- 495009
*Corresponding Author

Published In:   Volume - 10,      Issue - 12,     Year - 2017


ABSTRACT:
Highly polymorphic nature of the mitochondrial DNA (mtDNA) at the level of population having precise variants of mtDNA influences function mitochondria. Promising confirmation that mechanism at mitochondrial are vital to commonly occurred human diseases, it is believable that variants of mtDNA became a factor to the “missing heritability” of various multifaceted traits. mtDNA genes plays a essential task of oxidative phosphorylation, the alike genetic variants likely to modify the chance of developing a number of diverse disorders, but to date this has not been shown and explained in systematic manner. Numerous facts suggest that mitochondria plays key role in ageing-associated neurodegenerative disorders. Furthermore, haplogroups of mitochondria are related to several aspects of medicine, from habitual ageing to diseases, together with neurodegeneration. Mitochondrial genome polymorphisms might cause troubled generation of energy and leads to formation of large amount of reactive oxygen species, having capability of either susceptibility or shielding role in multiple diseases. In the present review, we emphasize the function of the mitochondrial haplogroups in the pathogenetic rise cause of diseases.


Cite this article:
I. Arjun Rao, Moumita Sinha, Manju Sahu , Bharati Ahirwar. Disease Association of Mitochondrial DNA haplogroups. Research J. Pharm. and Tech 2017; 10(12): 4445-4450. doi: 10.5958/0974-360X.2017.00819.8


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DOI: 10.5958/0974-360X 

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