ABSTRACT:
An in situ gel drug delivery is a novel idea of delivering drugs as a liquid dosage. The advantages shown by in situ forming polymeric delivery systems are ease of administration, improved patient compliance, deliverance of acute dose as well as to prolong residence time of drug in gastric mucosa. Lansoprazole is a proton pump inhibitor belonging to a class of anti-secretory compounds that suppress gastric acid secretion by specific inhibition of the (H+-K+) ATPase enzyme system at the secretory surface of the gastric parietal cell. The drug has shorter half-life and requires multiple administrations. The present study deals with the development and evaluation of the oral sustained release of Lansoprazole from in situ gelling sodium alginate, Carbopol-936 and HPMC E5NV formulations. In situ gelling solutions were prepared by varying the concentrations of sodium alginate (1% and 2%), Carbopol (1% and 2%) and HPMC/sodium alginate with distilled water and stirred continuously with mechanical stirrer. Then sodium citrate (0.23%w/v) and Lansoprazole (150mg) were added and stirred. Lansoprazole In situ gelling solutions were characterized by physiochemical properties, viscosity, drug content, gelling capacity, In-vitro release studies, floating capacity and stability studies. The drug release of Lansoprazole from gel solutions was found to be around 96.4%. Based on these results, it is concluded that a sustained release of Lansoprazole is achievable using In situ gelling floating system.