Author(s): P. Govardhan Reddy, V. Kiran Kumar, VVSS. Appala Raju, J.Raghu Ram, N. Appala Rraju

Email(s): rajnemala25@gmail.com

DOI: 10.5958/0974-360X.2017.00789.2   

Address: P. Govardhan Reddy1, V. Kiran Kumar1, VVSS. Appala Raju2 J.Raghu Ram3, N. AppalaRraju3*
1Department of Pharmaceutics, Unity college of Pharmacy, Raigir (V), Bhongir (M), Yadagiri(D), Telanagan State. 2Deparment of Chemistry, Faculty of Pharmacy, MAHSA University, Koula Lumpur, Malaysia.
3Department of Pharmaceutical Chemistry, Sultan Ul-Uloom College Of Pharmacy, Mount Pleasant, 8-2-249, Road No.3, Banjara Hills, Hyderabad, Telangana – 50034, India
*Corresponding Author

Published In:   Volume - 10,      Issue - 12,     Year - 2017


ABSTRACT:
A New, Simple, Rapid and economical extractive spectrophotometric methods were developed for the determination of Boceprevir (anti-retroviral drug). Boceprevir is a direct acting protease inhibitor for the treatment of hepatitis C. It also has two isomers in which the S isomer is more active than the R-isomer. The methods were based on the formation of color chromogens with Bromo cresol green, Bromo thymol blue, Bromo phenol blue and Methyl orange indicator. The extractive spectrophotometry was carried out with phthalate buffer and chloroform. The absorbances of the chromogens were measured at 410 nm and 415 nm against the corresponding reagent blank. The proposed methods have been successfully applied to the bulk drug. The method has been statistically evaluated and was found to be precise and accurate.


Cite this article:
P. Govardhan Reddy, V. Kiran Kumar, VVSS. Appala Raju, J.Raghu Ram, N. Appala Rraju. Novel Spectrophotometric Method Development for the Estimation of Boceprevir in Bulk and in Pharmaceutical Formulations. Research J. Pharm. and Tech 2017; 10(12): 4313-4316. doi: 10.5958/0974-360X.2017.00789.2


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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