Author(s): Shovit Ranjan, Praveen Kumar Sharma

Email(s): pksharma.cuj@gmail.com

DOI: 10.5958/0974-360X.2017.00787.9   

Address: Shovit Ranjan, Praveen Kumar Sharma*
Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi- 835205, Jharkhand, India
*Corresponding Author

Published In:   Volume - 10,      Issue - 12,     Year - 2017


ABSTRACT:
The aim of the study was to evaluate the association between diagnosis Type 2 Diabetes and Obesity (T2DO) and brain-derived neurotrophic factor (BDNF) gene polymorphism 196 G/A. The association between T2DO and the G196A polymorphism in the BDNF gene has already been investigated in several case-control studies, producing contradictory results. In order to explore these contradictory findings, the authors conducted a meta-analysis along with Trial Sequential Analysis (TSA) of BDNF 196 G/A polymorphism and T2DO in all the available case-control studies on the topic published from 2002 to 2016. We considered 8 case-control studies of the BDNF 196 G/A polymorphism associated with T2DO. Results showed significant association between BDNF 196 G/A allelic polymorphism and T2DO in Asian population. The present comprehensive meta-analysis suggested that further studies focusing on larger sample-size multi-ethnicity studies with homogeneous T2DO patients and well-matched controls are needed for future study to confirm the results of the study.


Cite this article:
Shovit Ranjan, Praveen Kumar Sharma. Association of Brain-Derived Neurotrophic factor (BDNF) gene SNP G196A with Type 2 Diabetes and Obesity: A Meta- Analysis. Research J. Pharm. and Tech 2017; 10(12): 4297-4305. doi: 10.5958/0974-360X.2017.00787.9

Cite(Electronic):
Shovit Ranjan, Praveen Kumar Sharma. Association of Brain-Derived Neurotrophic factor (BDNF) gene SNP G196A with Type 2 Diabetes and Obesity: A Meta- Analysis. Research J. Pharm. and Tech 2017; 10(12): 4297-4305. doi: 10.5958/0974-360X.2017.00787.9   Available on: https://rjptonline.org/AbstractView.aspx?PID=2017-10-12-38


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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