ABSTRACT:
Background: Immune system plays a vital role in protective mechanism against the foreign particles and its modulation either suppression or stimulation was implicated in several human diseases like inflammatory, infectious and autoimmune diseases etc. for which several allopathic immunomodulators has been used for treatment, exhibits potential side effects. Biological active compounds from natural sources used in the treatment of immune related disorder. Objective: Being the importance of natural compound, the present study was aimed to evaluate the immunomodulatory activity of Salvia hispanica.L seeds by in-vitro methods. Method: The immunomodulatory effect of hexane extract on phagocytosis and stimulation and activation of neutrophils were studied by using bactericidal activity, NBT Test, phagocytosis of killed Candida albicans and congo red stained yeast cells methods. Results: The extract exhibited the immunomodulatory effect by causing significant increase in phagocytosis and stimulation and their intercellular killing property of neutrophils support the immunomodulation due to presence of active compounds in extract. Conclusion: Results summarises the immunomodulatory activity of hexane extract of Salvia hispanica.L seeds due to presence of active constituents like fatty acids, essential oils etc.