Infections by enterococci have traditionally been treated with cell wall active agents such as penicillin or ampicillin in combination with an aminoglycoside (streptomycin / gentamicin), however emergence of high level resistance to aminoglycosides (HLAR), ß lactam antibiotics and to vancomycin by some strains, together with association of HLAR with multi drug resistance has led to failure of synergistic effects of combination therapy. A sum of 20 clinical isolates of Enterococci were tested for antibiotic sensitivity pattern followed by the detection of HLAR status. 11/20 (55%) were found to be HLAR Enterococcus spp, in which 9/11 (81.8%) were in E. faecalis and 2/11 (18.1%) in E. faceium. As Enterococcus species is one of the very important nosocomial pathogen appeared to resist multitude of antibiotics particularly aminoglycosides, it is important to screen for HLAR status for proper outcome of patients.
Cite this article:
K.B.S. Ananda Deeban, P. Gopinath. Detection of High Level Aminoglycoside Resistance (HLAR) among clinical isolates of Enterococci. Research J. Pharm. and Tech 2017; 10(12): 4195-4197. doi: 10.5958/0974-360X.2017.00765.X