Cystic fibrosis is an inherited disease which is characterized by the formation of thick sticky mucus in the lungs, pancreas, intestine, liver and kidneys. The cause of infection is a mutated cystic fibrosis transmembrane conductance regulator (CFTR) protein which disrupts the chloride channel functions. In order to get rid of cystic fibrosis effectively without side effects, the phytoconstituents of the plant Boswellia serrata, Panax ginseng, Ginkgo biloba, Echinacea angustifolia were analyzed for its efficient binding with the target protein. The 3D structure of CFTR was retrieved from the PDB ID: 4WZ6. The compound echinasoide had significant interactions with protein and the observed G.score was -6.94kcal/mol. The 3 interactions were observed with the residues threonine, serine, and glycine of bond length 2.0, 2.2, 2.4Å.
Cite this article:
R. Sathish Kumar, B. Lakshmi Priya. A Mutated Transmembrane Conductance Regulator Protein Targeted for Cystic Fibrosis– An In silico Analysis. Research J. Pharm. and Tech 2017; 10(11): 3697-3700. doi: 10.5958/0974-360X.2017.00670.9