Skin disease is most common form of contagious infections occurs among all ages of people. Impetigo is one such skin infection than can spread from one person to another which appears as sores on the skin that are often covered by a thick dry honey-colored crust. Though the sores have no hurt, it has a tender feel when touched. Impetigo is usually caused by either Streptococcus or Staphylococcus bacteria, which are normally found on the skin and in the nose. When small cuts, scratches, or insect bites occur, these bacteria can get under the skin surface and cause infection. Children and adults can get impetigo, though children get it more often. The aim of this study is to identify the lead molecules to develop drug against impetigo from the medicinal plants. Here, the plants like Aloe vera, Curcuma longa, Lantana camara, and Euphorbia hirta are selected and docking was carried out to find the binding efficiency of the plant compounds with the antibacterial targets. Among Aloe vera showed significant result where 16 compounds were found active, those are carminic acid (11.83 Kcal/mol), 2-Anthroquine sulfonic acid (10.75 Kcal/mol), leucine (6.70 Kcal/mol), omannopyranosyltheronine (6.47 Kcal/mol), methionine (5.64 Kcal/mol) and carbobenzyloxyglycine (5.13 Kcal/mol). From the study it was concluded that compounds from Aloe vera could be used in future to develop a drug molecule using various computational and biotechnological techniques.
Cite this article:
R. Sathish Kumar, S. Navatheesh. In silico Screening of Lead Molecule from Medicinal Plants for Bacterial Skin Disease- Impetigo. Research J. Pharm. and Tech 2017; 10(11): 3687-3691. doi: 10.5958/0974-360X.2017.00668.0
R. Sathish Kumar, S. Navatheesh. In silico Screening of Lead Molecule from Medicinal Plants for Bacterial Skin Disease- Impetigo. Research J. Pharm. and Tech 2017; 10(11): 3687-3691. doi: 10.5958/0974-360X.2017.00668.0 Available on: https://rjptonline.org/AbstractView.aspx?PID=2017-10-11-6