Author(s): Khushboo, Atul Kumar Sahu, Raj K. Prasad

Email(s): sinha08khusi@gmail.com

DOI: 10.5958/0974-360X.2017.00710.7   

Address: Khushboo*, Atul Kumar Sahu, Raj K. Prasad
Shambhunath Institute of Pharmacy, Jhalwa, Near IIIT, Allahabad, (U.P)-India-211012
*Corresponding Author

Published In:   Volume - 10,      Issue - 11,     Year - 2017


ABSTRACT:
The aim of present work is to develop Clarithromycin nanoparticles for controlled release, improved drug efficacy, reducing drug toxicity and prolong the half lives in blood. Clarithromycin loaded nanoparticles were prepared by solvent displacement or solvent precipitation method using acrylic polymer (Eudragit RS 100). The nanoparticles were prepared in six batches by varying the concentration of Eudragit RS 100 and the stabilizing agent PVA. Nanoparticles were characterized for percentage nanoparticles, particle size, entrapment efficiency, scanning electron microscopy, zeta potential, in vitro drug release, in vitro antimicrobial studies and stability studies. The nanoparticle formulation CLN-F1 which was prepared using incorporating the highest amount of polymer and had 1% of PVA showed maximum entrapment efficiency and particle size of 290.2±3 nm. Polymer concentration in the internal phase is a crucial factor in increasing the size of nanoparticles. When the polymer concentration increased, size of nanoparticles also got increased. SEM studies were carried out for all the formulations which revealed that they were spherical in shape.


Cite this article:
Khushboo, Atul Kumar Sahu, Raj K. Prasad. Formulation Development and Evaluation of Clarithromycin Nanoparticles Using Acrylic Polymer. Research J. Pharm. and Tech 2017; 10(11): 3907-3918. doi: 10.5958/0974-360X.2017.00710.7

Cite(Electronic):
Khushboo, Atul Kumar Sahu, Raj K. Prasad. Formulation Development and Evaluation of Clarithromycin Nanoparticles Using Acrylic Polymer. Research J. Pharm. and Tech 2017; 10(11): 3907-3918. doi: 10.5958/0974-360X.2017.00710.7   Available on: https://rjptonline.org/AbstractView.aspx?PID=2017-10-11-49


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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