ABSTRACT:
In the current study, Fifty six patients of Pulmonary arterial hypertension were admitted from Echocardiography unit and Najaf Cardiac Centre in Al-Sadder Teaching City in Al- Najaf province/ Iraq during September 2016 to February 2017, divided into six groups:-First group according to gender ( Male= 34 , Female = 22 )Second group according to the type of disease ,primary included 20 patients and secondary 36 group , Third group according to Smoking included smokers 26 subjects and nonsmokers patients group included 30 subjects, Fourth group according to the type of secondary pulmonary hypertension ( Vulvular 24, Chronic Obstructive Pulmonary Disease 18 and Congenital 14) ,fifth group according to ages (30 – 39 year =12 ,40 – 49 year = 12 , 50 – 59 year= 12 , 60 – 69 year = 20) , six group according to Grades ([ Mild = 18 , moderate = 18 , severe; 20).The control group was composed of thirty healthy subject. The results showed there was a significant increase (p<0.05) in Gremlin -1 serum level in patients of PAH in compared with healthy group, also the results revealed a significant increase (p<0.05) in Gremlin -1 in Males in compared with Females , Secondary PAH than Primary , smokers in compared with Nonsmokers . and Chronic Obstructive Pulmonary Disease compared with Congenital and Vulvular, Severe grades than Mild and Moderate and non significant differences between aged groups . Conclusion: The current results concluded that Gremlin -1 is a marker for detection and diagnosis of Pulmonary arterial hypertension .