Author(s): Sachin S. Mali, Suresh G. Killedar

Email(s): sachinmali143@gmail.com

DOI: 10.5958/0974-360X.2017.00683.7   

Address: Sachin S. Mali*, Suresh G. Killedar
Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, India
*Corresponding Author

Published In:   Volume - 10,      Issue - 11,     Year - 2017


ABSTRACT:
Metoprolol succinate is a selective beta receptor blocker having poor physico-chemical and micromeritic properties. Therefore the co-crystals of metoprolol have been attempted to improve its physic-chemical and micromeritic characteristics. The effect of different co-formers such as benzoic acid and salicylic acid on flow ability of metoprolol by co-crystal technique. The co-crystals were characterized by Infra-red spectroscopy(I.R).It was found that micromeritic properties such as angle of repose, and physicochemical properties such as melting point. of co-crystals were significantly improved than that of pure metoprolol succinate. Hence it could be concluded that co-crystals could be one of the effective approaches for improved performance of metoprolol succinate.


Cite this article:
Sachin S. Mali, Suresh G. Killedar. To Enhance the Physicochemical Properties of Metoprolol Succinate By Co-Crystal Technique. Research J. Pharm. and Tech 2017; 10(11): 3761-3767. doi: 10.5958/0974-360X.2017.00683.7


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DOI: 10.5958/0974-360X 

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