Author(s): Bibaswan Mishra, Prasanta Kumar Biswal, Nihar Ranjan Pani, Prasanna Kumar Dixit

Email(s): drbibaswanmishra@gmail.com

DOI: 10.5958/0974-360X.2017.00625.4   

Address: Bibaswan Mishra1*, Prasanta Kumar Biswal2, Nihar Ranjan Pani2, Prasanna Kumar Dixit3
1Institute of Pharmacy and Technology, Salipur, Cuttack, Odisha, India
2Gayatri College of Pharmacy, Sambalpur, Odisha, India
3Department of Zoology, Berhampur University, Ganjam, Odisha, India
*Corresponding Author

Published In:   Volume - 10,      Issue - 10,     Year - 2017


ABSTRACT:
The present study aims to design and develop a self- micro-emulsifying tablets of cinnarizine with a suitable adsorbent of self microemulsion liquid to enhance the dissolution and oral bioavailability. The tablets were prepared by wet granulation compression of the self-micro-emulsifying granules. The granules were characterized through flow property. Droplet size distribution of disintegrated SMET emulsion sample was found to be within 3.86 ± 3.77 to 5.41 ± 2.93 µm which infers that all the SMETs showed good emulsification properties with low globule size. The tablets were tested for weight variation, friability, hardness, drug content, disintegration and in-vitro dissolution profile. The pharmacokinetic study of SMET of cinnarizine formulation was performed in rabbits and the pharmacokinetic parameters were compared with a piece of commercial tablet. The tablets showed acceptable physical properties with disintegration time less than 13 sec. The dissolution profile of selected formulation revealed more than 80 percent drug released in just 5 minutes. The pharmacokinetic parameters such as Cmax and AUC0-8 of F7 found 1.5 and 1.8 times more than that of commercial product respectively. The results infer that the prepared of SMET formulation of cinnarizine is a potential formulation with profound reproducibility may be manufactured for commercial batch.


Cite this article:
Bibaswan Mishra, Prasanta Kumar Biswal, Nihar Ranjan Pani, Prasanna Kumar Dixit. In-vitro Characterization and Pharmacokinetic investigation of self-Micro-Emulsifying Tablets of Cinnarizine. Research J. Pharm. and Tech 2017; 10(10):3492-3497. doi: 10.5958/0974-360X.2017.00625.4


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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