Author(s): Hussein Akel, FatenMadani, Wehad Ibrahim

Email(s): hussein.akel@hotmail.com , fatenmadani@yahoo.fr , wehadibrahim@yahoo.com

DOI: 10.5958/0974-360X.2017.00580.7   

Address: Hussein Akel1*, FatenMadani2, Wehad Ibrahim2
1Master Student in Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Tishreen University, Syria.
2Doctor in Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Tishreen University, Syria.
*Corresponding Author

Published In:   Volume - 10,      Issue - 10,     Year - 2017


ABSTRACT:
The objective of this study is to prepare Paracetamol Microcapsules using Gelatin type A and Gum Arabic as a hydrophilic polymers. Microcapsules were prepared by complex Coacervation. Microencapsulation Yield “MEY” and microencapsulation efficiency “MEE” were investigated with respond to three variables including: core to wall ratio (2:1, 4:1, 6:1), Stirring Speed (200, 300, 400) rpm and Drying method (Air at room temperature, Air oven at 26ºC). Isopropanol was added to some preparations as a crosslinking agent and its effect on MEY and MEE was also investigated with respond to each variable. The results showed that increasing core to wall ratio leads to an increase in both MEE and MEY. The same effect was obtained when increasing stirring speed. The change in a way drying leads to insignificant change in both MEE and MEY. Optimum MEE and MEY were obtained when using core to wall ratio of 6:1, 400 rpm in both two ways of drying. Adding isopropanol as hardening agent had no noticeable effects on both MEE and MEY.


Cite this article:
Hussein Akel, FatenMadani, Wehad Ibrahim. Preparation of Paracetamol Microcapsules by Complex Coacervation and Studying the effect of some Factors Influencing Microencapsulation Yield and Efficacy. Research J. Pharm. and Tech 2017; 10(10):3271-3275. doi: 10.5958/0974-360X.2017.00580.7


Recomonded Articles:

Author(s): V. Swathi, G. Velrajan, Balasubramaniam

DOI: Not Available         Access: Open Access Read More

Author(s): RS Kamble, BV Bakde, MA Channawar, RL Bakal, SR Gawande, AV Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): S.S. Manikiran, S.N.H. Pratap, N.L. Prasanthi, N. Ramarao

DOI: Not Available         Access: Open Access Read More

Author(s): Shinde AD, Bhise SB

DOI: Not Available         Access: Open Access Read More

Author(s): S.D. Ghanchi, S.C. Dhawale

DOI: Not Available         Access: Open Access Read More

Author(s): Archana D. Kajale, Chandrashekhar K. Gadewar, Prafful P. Kothari

DOI: 10.5958/0974-360X.2020.00046.3         Access: Closed Access Read More

Author(s): Sapna Kashyap, Amit Singh, Ajeet Madhukar Godbole, Sandesh Narayan Somnache

DOI: 10.5958/0974-360X.2018.00308.6         Access: Open Access Read More

Author(s): Mali Snehal D., Khochage Swapna R., Nitalikar Manoj M., Magdum Chandrakant S

DOI: Not Available         Access: Open Access Read More

Author(s): Simran Kukreja, Sonal Priya, Shraddha Bhondekar, Nupur Verma, Sonal Jain, Aivant Golchha, Ganesh Sinha, Shubham Kumar, Chandan Mandal, Asha Patel, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00215.3         Access: Open Access Read More

Author(s): U. D. Shivhare, G. S. Chhabra, V. B. Mathur, S. B. Patel

DOI: Not Available         Access: Open Access Read More

Author(s): M. Surendra, T. Venkateswara Rao, K. Lokeswara Reddy, A. Ramesh Babu

DOI: Not Available         Access: Open Access Read More

Author(s): N.N. Bobade, S.D. Pande, K. K. Tapar, P.V. Ambalkar, S.P. Malviya

DOI: 10.5958/0974-360X.2016.00057.3         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags