Author(s): Jeyabaskar Suganya, Mahendran Radha, Sharanya Manoharan, Vinoba. V, Astral Francis

Email(s): suganyaj11@gmail.com

DOI: 10.5958/0974-360X.2017.00596.0   

Address: Jeyabaskar Suganya*, Mahendran Radha, Sharanya Manoharan, Vinoba. V, Astral Francis
Department of Bioinformatics, School of Life Sciences, Vels University, Chennai-600117, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 10,     Year - 2017


ABSTRACT:
Diabetes is one of the most serious metabolic disorders across the world which affects all age groups. World Health Organization (WHO) ranked the top diabetic countries in which India was ranked among the top three which diagnosed 62 million people. So there is an urgent need for the discovery of novel natural anti-diabetic drugs without any side effects. On analyzing the anti-diabetic plants, Momordica charantia exhibited better pharmacological properties and its bioactive compounds, which was found to possess good anti-diabetic activity were selected through literature for in silico studies. There were 51 bioactive compounds found in Momordica charantia, out of which only 13 compounds were carried out for the next step of analysis whose molecular properties satisfies to be a new lead for drug molecules. Further literature studies on diabetes showed that the enzyme glucokinase involved in the metabolic pathway for the production of energy were mostly responsible for causing diabetes in humans. For docking analysis, Arguslab software was used for screening the binding affinity between the inhibitors and target protein. The result of docking analysis revealed that compound nerolidol from Momordica charantia exhibited best binding interaction with diabetic protein. The nerolidol compound predicted from this research could be carried for in vivo analysis in future for the designing of novel potential drugs in the treatment of diabetes.


Cite this article:
Jeyabaskar Suganya, Mahendran Radha, Sharanya Manoharan, Vinoba. V, Astral Francis. Virtual Screening and Analysis of Bioactive Compounds of Momordica charantia against Diabetes using Computational Approaches. Research J. Pharm. and Tech 2017; 10(10):3353-3360. doi: 10.5958/0974-360X.2017.00596.0


Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): P.Maheshwari, D.Pavithra, Neethu.T.T, T.S. Shanmugarajan, P. Shanmugasundaram

DOI: 10.5958/0974-360X.2017.00011.7         Access: Open Access Read More

Author(s): S. Subasree, Karthikeyan Murthykumar, Dhanraj

DOI: 10.5958/0974-360X.2016.00116.5         Access: Open Access Read More

Author(s): Koushika Das, Pranit Krishna, Avipsha Sarkar, Shanmuga Sundari Ilangovan, Shampa Sen

DOI: 10.5958/0974-360X.2017.00267.0         Access: Open Access Read More

Author(s): Abhirup Dey, Mangala Lakshmi Ragavan, Sanjeeb Kumar Mandal, Nilanjana Das

DOI: 10.5958/0974-360X.2017.00136.6         Access: Open Access Read More

Author(s): Santhosh Kumar V, Praveen D

DOI: 10.5958/0974-360X.2016.00123.2         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Leelavathi D Acharya, N R Rau, N Udupa, Surulivel Rajan M, Vijayanarayana K

DOI: 10.5958/0974-360X.2016.00162.1         Access: Open Access Read More

Author(s): A. Julius, Ramachandran Vedasendiyar, Archana Devakannan, Sujatha Rajaraman, Balamurugan Rangasamy, V. Saravanan

DOI: 10.5958/0974-360X.2017.00062.2         Access: Open Access Read More

Author(s): Praveen D, Ranadheer Chowdary P, Gandikota Thanmayi, Gangabathina Poojitha, Vijey Aanandhi M

DOI: 0.5958/0974-360X.2016.00047.0         Access: Open Access Read More

Author(s): Kousalya M., Geetha P., Jesuraja A., Vinoth Kumar M

DOI: 10.5958/0974-360X.2017.00014.2         Access: Open Access Read More

Author(s): S.M. Charjan, S.K. Bais, R.R. Shiradkar, R.L. Bakal, V.M. Durge, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Vaddi Mounika, S. Sarumathy, J. Anisha Ebens, T. S. Shanmugarajan

DOI: 10.5958/0974-360X.2017.00003.8         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags