This study was conducted to detect the role Tumor Necrosis Factor- Alpha in Hepatitis C virus infected patients and type 2 diabetes mellitus induction. The study included 150 hepatitis C virus suspected patients attending Al-Hakeem Hospital/Central Laboratory in Al-Najaf province, over a period of 7 months from August (2014) to 7 February (2015), there ages ranged from (14-67) years old from both genders. Hepatitis C virus infection and diabetes mellitus detected based on clinical and laboratory investigations e, sixty four patients were found to be seropositive result to Hepatitis C virus , fourteen of HCV infected patients have type 2 diabetes mellitus and Eighteen individuals without any signs or symptoms of disease were selected as normal control group.
Serum level of tumor necrosis factor- alpha was measured through enzyme linked immunosorbant assay technique, the level of tumor necrosis factor- alpha showed a high significance (P<0.05) elevation in the serum of all patients than control. Also the hepatitis C virus with type 2 diabetes mellitus patients have an increased level of tumor necrosis factor-alpha (194.4pg/ml) than HCV patients without diabetes(124.6pg/ml), but these increase not significantly .Statistical analysis showed a positive association between HCV seropositive and tumor necrosis factor- alpha. Increment of serum level in HCV infected patients may lead to developed type 2 diabetes mellitus.
Cite this article:
Evaluation of Tumor Necrosis Factor- Alpha in Hepatitis C Virus with Diabetes Mellitus and Non Diabetes Mellitus patients. Research J. Pharm. and Tech 2017; 10(10):3260-3263. doi: 10.5958/0974-360X.2017.00578.9