Author(s):
R. Pavithra, K. Hemalatha, K. Girija
Email(s):
Email ID Not Available
DOI:
10.5958/0974-360X.2017.00595.9 
Address:
R. Pavithra, K. Hemalatha, Dr. K. Girija*
Department of Pharmaceutical Chemistry, College of Pharmacy,
Mother Theresa Post Graduate and Research Institute of Health Sciences,
(A Government of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry-06
*Corresponding Author
Published In:
Volume - 10,
Issue - 10,
Year - 2017
ABSTRACT:
A series of some novel 1,2-disubstituted benzimidazole derivatives were synthesized by condensing 2-substituted benzimidazole with various primary amino compounds. The purity of synthesized compounds was confirmed by melting point determination and thin layer chromatography method. The chemical structure of synthesized compounds was characterized using IR-Spectroscopy. The compounds were docked against the target enzyme Biotin Carboxylase. The compounds showed significant binding energy (PA4, PA5, PA6, PA10) were evaluated for their in vitro anti-bacterial activity against Staphylococcus aureus and Salmonella typhi by well diffusion method using the standard drug Chloramphenicol. Among the tested compound PA 5 and PA6 shows significant anti-bacterial activity.
Cite this article:
R. Pavithra, K. Hemalatha, K. Girija. Eco-Friendly Synthesis, Characterization, Docking and Anti-Bacterial activity of Mannich Base Substituted Benzimidazoles. Research J. Pharm. and Tech 2017; 10(10):3346-3352. doi: 10.5958/0974-360X.2017.00595.9
Cite(Electronic):
R. Pavithra, K. Hemalatha, K. Girija. Eco-Friendly Synthesis, Characterization, Docking and Anti-Bacterial activity of Mannich Base Substituted Benzimidazoles. Research J. Pharm. and Tech 2017; 10(10):3346-3352. doi: 10.5958/0974-360X.2017.00595.9 Available on: https://rjptonline.org/AbstractView.aspx?PID=2017-10-10-19