Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

Email(s): ushaynayak@gmail.com

DOI: 10.5958/0974-360X.2017.00007.5   

Address: Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal – 576104
*Corresponding Author

Published In:   Volume - 10,      Issue - 1,     Year - 2017


ABSTRACT:
The aim of the work was to prepare co-crystals of valsartan, a BCS Class II drug to enhance its aqueous solubility and bioavailability. The solvent evaporation method was used to prepare co-crystals by using different co-formers and varying the drug to co-former molar ratios. Succinic acid was found to be suitable co-former to prepare co-crystals with good physico-chemical properties. The solid state characterization of co-crystals were studied by FTIR, DSC and XRD. The co-crystals were evaluated for the saturation solubility and dissolution studies. Solubility study in distilled water indicated low solubility of valsartan (198.5 µg/ml), there was 2.6 fold increase in the solubility of co-crystals prepared using succinic acid, with 1:5 drug to co-former ratio (520.6 µg/ml). Solid state characterizations indicated there was no change in the chemical nature of the co-crystals compared to pure drug. Presence of crystalline co-former induced crystallinity to the developed co-crystals. Thus developed co-crystals were found to be suitable alternative to increase the solubility and dissolution rate of valsartan.


Cite this article:
Jino Elsa Thomas, Usha Y Nayak, Jagadish PC, Koteshwara KB. Design and Characterization of Valsartan Co-Crystals to Improve its Aqueous Solubility and Dissolution Behavior. Research J. Pharm. and Tech. 2017; 10(1): 26-30. doi: 10.5958/0974-360X.2017.00007.5


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 


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