Author(s): Radha Rani Earle, Vinod Kumar Tedlapu, Lakshmi Usha Ayalasomayajula

Email(s): radhaearle@yahoo.com

DOI: 10.5958/0974-360X.2017.00061.0   

Address: Radha Rani Earle*, Vinod Kumar Tedlapu, Lakshmi Usha Ayalasomayajula
Department of Pharmaceutical Technology, Maharajah’s College of Pharmacy, Vizianagaram, India.
2Pfizer, Visakhapatnam, India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 1,     Year - 2017


ABSTRACT:
The purpose of the present study was to enhance the solubility and dissolution rate of a poorly water soluble drug by forming inclusion complexes. Irbesartan was used as a model drug to evaluate its release characteristics from the formulations. The phase solubility studies of Irbesartan were conducted in the presence of various concentrations of ß-CD and HP ß-CD. ?Gtr0 values were all negative for the carriers at various concentrations, indicating the spontaneous nature of drug’s solubilization, and it decreased with an increase in its concentration, demonstrating that the reaction became more favorable as the concentration of carrier increased. The drug solubility increased linearly with increasing polymer concentration indicative of the AL type of solubility phase diagram. Inclusion complexes of Irbesartan were prepared by kneading technique in various concentrations of drug: carrier. The dissolution profiles of the complexes were compared with those of the pure drug. All the inclusion complexes exhibited higher rates of dissolution values than Irbesartan pure drug and corresponding physical mixtures. Characterization of the solid dispersions was carried out by Differential Scanning Calorimetry (DSC) and Fourier Transform Infra-Red spectroscopy (FTIR).


Cite this article:
Enhancement of Dissolution Rate and Physicochemical Characterization of Irbesartan Inclusion Radha Rani Earle, Vinod Kumar Tedlapu, Lakshmi Usha Ayalasomayajula. Complexes using Cyclodextrins. Research J. Pharm. and Tech. 2017; 10(1): 301-306. doi: 10.5958/0974-360X.2017.00061.0

Cite(Electronic):
Enhancement of Dissolution Rate and Physicochemical Characterization of Irbesartan Inclusion Radha Rani Earle, Vinod Kumar Tedlapu, Lakshmi Usha Ayalasomayajula. Complexes using Cyclodextrins. Research J. Pharm. and Tech. 2017; 10(1): 301-306. doi: 10.5958/0974-360X.2017.00061.0   Available on: https://rjptonline.org/AbstractView.aspx?PID=2017-10-1-61


Recomonded Articles:

Author(s): Ahmed Hilal Sheriff, Preetham Prasad Nittla

DOI: 10.5958/0974-360X.2019.00968.5         Access: Open Access Read More

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Justin Antony, Satadal Debroy, Chennu Manisha, Peet Thomas, Victoria Jeyarani, Tenzin Choephel

DOI: 10.5958/0974-360X.2019.00367.6         Access: Open Access Read More

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Mythili. L, GNK. Ganesh, C. Monisha, Kayalvizhi. R

DOI: 10.5958/0974-360X.2019.00426.8         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Pande S. D., Wagh A.S., Bhagure L.B., Patil S.G., Deshmukh A.R.

DOI: 10.5958/0974-360X.2015.00070.0         Access: Open Access Read More

Author(s): Mohd Yousuf Ali, Md Shamim Qureshi, Md Hamed, Byasabhusan Das and K Purushotham Rao

DOI: Not Available         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Karpagam T, Jannathul Firdous, Revathy, Shanmuga Priya, Varalakshmi B, Gomathi S, Geetha S, Noorzaid Muhamad

DOI: 10.5958/0974-360X.2019.00360.3         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags