Author(s): Hemalatha C N, Anbarasu K, Vijey Aanandhi M

Email(s): hodpchemistry@velsuniv.ac.in

DOI: 10.5958/0974-360X.2017.00060.9   

Address: Hemalatha C N1, Anbarasu K2, Vijey Aanandhi M1*
1Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Vels University (VISTAS), Chennai, India
2Department of Pharmacology, KMCH College of Pharmacy, Coimbatore. India
*Corresponding author

Published In:   Volume - 10,      Issue - 1,     Year - 2017


ABSTRACT:
Cancer is one of the major diseases and challenging to medicinal system to produce potent and the site specific anti-cancer drugs. In this cancer studies up to now most of the synthetic drugs produce undesirable side effects. At the same time from plant source produce potent and safer anti-cancer drugs than compare to synthetic drugs. Cissus quadrangularis is an important medicinal plant belonging to the family Vitaceae. In this study, the qualitative phytochemical studies by using ethanol and chloroform extracts, Toxicological studies by Acute toxicities studies (LD50), Pharmacological Evaluations of Anti-tumor activity and Biochemical parameters are estimated and Anti-Oxidant Assay of C.quadrangularis were evaluated. The secondary metabolites such as phenol, glycosides, tannins and flavonoids were present in the ethanolic extract of C.quadrangularis. The DMBA breast cancer model is a well-known animal carcinogenesis model. CQ extracts possesses anti-tumor property as evidenced by its significant inhibition in the formation of tumor induced by chemical carcinogen (DMBA). From the results , it can be concluded that chloroform & ethanolic extract of CQ restored the biochemical imbalance occurred due to DMBA administration as well as lowered the tumor incidences and burden, the results obtained with the ethanolic extract were promising as compared to that of chloroform extract. Thus it may be useful for the treatment of mammary carcinoma and associated complications such as oxidative damage.


Cite this article:
Hemalatha C N, Anbarasu K, Vijey Aanandhi M. Evaluation of Anti-Cancer and Anti-Oxidant Activity of Cissus quandrangularis Extracts in DMBA induced Mammary Carcinomas. Research J. Pharm. and Tech. 2017; 10(1): 293-300. doi: 10.5958/0974-360X.2017.00060.9


Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): P.Maheshwari, D.Pavithra, Neethu.T.T, T.S. Shanmugarajan, P. Shanmugasundaram

DOI: 10.5958/0974-360X.2017.00011.7         Access: Open Access Read More

Author(s): R. Narayana Charyulu, P. Parvathy Devi, Jobin Jose, A. Veena Shetty

DOI: Not Available         Access: Open Access Read More

Author(s): Raj Kumar R, Praveen D, Palani Shanmugasundaram

DOI: 10.5958/0974-360X.2016.00164.5         Access: Open Access Read More

Author(s): Koushika Das, Pranit Krishna, Avipsha Sarkar, Shanmuga Sundari Ilangovan, Shampa Sen

DOI: 10.5958/0974-360X.2017.00267.0         Access: Open Access Read More

Author(s): Abhirup Dey, Mangala Lakshmi Ragavan, Sanjeeb Kumar Mandal, Nilanjana Das

DOI: 10.5958/0974-360X.2017.00136.6         Access: Open Access Read More

Author(s): Sandeep D. S, Prashant Nayak, Jobin Jose, Rishal Relita M, Sumana D. R.

DOI: 10.5958/0974-360X.2017.00317.1         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Leelavathi D Acharya, N R Rau, N Udupa, Surulivel Rajan M, Vijayanarayana K

DOI: 10.5958/0974-360X.2016.00162.1         Access: Open Access Read More

Author(s): H. Firdus Fareen, M.S. Thenmozhi

DOI: 10.5958/0974-360X.2016.00146.3         Access: Open Access Read More

Author(s): P. Geetha, M. Kousalya, S. Geetha Lakshmi, R. Gopi.

DOI: 10.5958/0974-360X.2016.00046.9         Access: Open Access Read More

Author(s): Pankaj Kumar, Jane Jacob, Khadjeeth Ajina, Jazeela, Fathima

DOI: 10.5958/0974-360X.2016.00101.3         Access: Open Access Read More

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Author(s): A. Julius, Ramachandran Vedasendiyar, Archana Devakannan, Sujatha Rajaraman, Balamurugan Rangasamy, V. Saravanan

DOI: 10.5958/0974-360X.2017.00062.2         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags