Author(s): I. Somasundaram, S. Sathesh Kumar

Email(s): somous0926@gmail.com

DOI: 10.5958/0974-360X.2017.00051.8   

Address: I. Somasundaram*, S. Sathesh Kumar
Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Vels University, Chennai-600117, India
*Corresponding author

Published In:   Volume - 10,      Issue - 1,     Year - 2017


ABSTRACT:
The present investigation was undertaken to develop nanoparticles of a hydrophilic drug pramipexole dihydrochloride and improve the entrapment efficiency of the drug. Pramipexole dihydrochloride nanoparticles where prepared with two methods by using Chitosan and another method by utilizing Chitosan, sodium alginate and Pluronic F-127. Five different trials were prepared with different concentrations of Chitosan in both methods. In two methods variables were found to have significant effect on the particle size, entrapment efficiency of drug which is influenced by Chitosan and sodium alginate. The maximum entrapment efficiency and least particle size were obtained with 3% Chitosan along with sodium alginate PS3 of 220.7 nm with 32.4 mV zeta potential with 91.2 % entrapment efficiency but in PC3 with 3% Chitosan show least particle size of 252nm with 44.7 mV zeta potential but less entrapment efficiency 82.8 % of than PS3.The surface morphology of PC3 and PS3 shows smooth surface with the in vitro release of PC3 with 90.2 %, PS3 with 96.12% in 24 hrs. PS3 shows better entrapment efficiency than PC3, Hence preparation methods along with two polymers may influence in entrapment efficiency of pramipexole dihydrochloride nanoparticles which meet the treatment of Parkinson’s disease which has a potential influence on brain-targeting.


Cite this article:
I. Somasundaram, S. Sathesh Kumar. Preparation and evaluation of Pramipexole dihydrochloride loaded chitosan nanoparticles for brain-targeting. Research J. Pharm. and Tech. 2017; 10(1): 245-251. doi: 10.5958/0974-360X.2017.00051.8


Recomonded Articles:

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Y. Prem Kumar, K. Vinod Kumar, V. Sai Kishore

DOI: Not Available         Access: Open Access Read More

Author(s): Saranya, Parthasarathy V, Hariprasad B, Shobha Rani H

DOI: 10.5958/0974-360X.2016.00233.X         Access: Open Access Read More

Author(s): Ankita Chatterjee, Jayanthi Abraham

DOI: 10.5958/0974-360X.2016.00125.6         Access: Open Access Read More

Author(s): N. Chandarsekaran, M. Balamurugan

DOI: Not Available         Access: Open Access Read More

Author(s): Rao Rekha, Goswami Anju, Shekhar Shishant, Mahant Sheefali, Nanda Sanju

DOI: Not Available         Access: Open Access Read More

Author(s): Baviskar Anagha, Hiremath Shivanand, Akul Manoj, Pawar Poonam

DOI: Not Available         Access: Open Access Read More

Author(s): Nandini R. Pai, Swapnali Suhas Patil

DOI: Not Available         Access: Open Access Read More

Author(s): A. Khuntia, S.K. Mohanty

DOI: Not Available         Access: Open Access Read More

Author(s): Priti Patel, Ashok Kumar P., Hemil Shah, Nikunj Patel, Pratik Kheni, Someshwara Rao B., Suresh V. Kulkarni, Babitha S.

DOI: Not Available         Access: Open Access Read More

Author(s): Mettu Srikanth Reddy, Mallikarjun Setty

DOI: Not Available         Access: Open Access Read More

Author(s): V. Swathi, G. Velrajan, Balasubramaniam

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags