Author(s): Fahad Khalid Aldhafiri, Balakrishnan Santhanaraj, Gokulan Selvam, Khader Syed Zameer Ahamed, Ramasamy Subbaiya, Suriya Kumaresan, Ponnusamy Ponmurugan.

Email(s): ramsubbubio@gmail.com

DOI: 10.5958/0974-360X.2017.00024.5   

Address: Fahad Khalid Aldhafiri, Balakrishnan Santhanaraj, Gokulan Selvam, Khader Syed Zameer Ahamed, Ramasamy Subbaiya, Suriya Kumaresan, Ponnusamy Ponmurugan.
1College of Applied Medical Sciences, Majmaah University, Al Majmaah, The Kingdom of Saudi Arabia.
2Department of Biotechnology, K. S. Rangasamy College of Technology, Tiruchengode- 637 215, Namakkal District, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 1,     Year - 2017


ABSTRACT:
Physiological activities of liver result in the generation of highly reactive free radicals and various biochemical reactions make liver cells prone to attack and necrosis also excessive release of reactive oxygen species results in the organ damage. Herbal drugs plays important role as antioxidant in the management of various liver disorders which can even speed up the natural healing processes of the liver. Barringtonia acutangula L. an evergreen tree of moderate size was used in various indigenous systems of medicine against several diseases and almost every part of the plant has diverse pharmacological properties. The hepatoprotective property of this plant extracts was analyzed in this study in which leaf extracts were obtained using methanol further phytochemical and antioxidant properties were analyzed. In vivo studies were carried out for hepatoprotective studies on CCl4 induced liver damage following histopathological studies of rat liver tissues to support the induction of hepatoprotective efficacy. The grouping of animals consists of 6 rats per group in which group I has CCl4 induced rats treated with Silymarin (100 mg/kg b.w) for 30 days, group II & III has CCl4 induced rats treated with methanolic extract of Barringtonia acutangula (250 mg/kg b.w) & (500 mg/kg b.w) for 30 days. Biochemical analysis reveals that the values of parameters of treated groups have become too normal compared to the control group. Histopathology results suggest that there is improvement in the cell counts and decrease in vacuoles. Therefore, results of in vivo and in vitro studies indicate that has more potential at 500 mg/kg b.w concentration.


Cite this article:
Fahad Khalid Aldhafiri, Balakrishnan Santhanaraj, Gokulan Selvam, Khader Syed Zameer Ahamed, Ramasamy Subbaiya, Suriya Kumaresan, Ponnusamy Ponmurugan.. Hepatoprotective Studies of Methanolic Leaf Extract of Barringtonia acutangula (L) against Carbon Tetrachloride Induced Liver Injury in Wistar Rats. Research J. Pharm. and Tech. 2017; 10(1): 101-107. doi: 10.5958/0974-360X.2017.00024.5


Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): Koushika Das, Pranit Krishna, Avipsha Sarkar, Shanmuga Sundari Ilangovan, Shampa Sen

DOI: 10.5958/0974-360X.2017.00267.0         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): A. Julius, Ramachandran Vedasendiyar, Archana Devakannan, Sujatha Rajaraman, Balamurugan Rangasamy, V. Saravanan

DOI: 10.5958/0974-360X.2017.00062.2         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Praveen D, Ranadheer Chowdary P, Gandikota Thanmayi, Gangabathina Poojitha, Vijey Aanandhi M

DOI: 0.5958/0974-360X.2016.00047.0         Access: Open Access Read More

Author(s): Kousalya M., Geetha P., Jesuraja A., Vinoth Kumar M

DOI: 10.5958/0974-360X.2017.00014.2         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): M. Dilip Kumar, S. Subash Sharma

DOI: 10.5958/0974-360X.2017.00073.7         Access: Open Access Read More

Author(s): Krishnendu Acharya*, Somanjana Khatua, Salman Sahid

DOI: Not Available         Access: Open Access Read More

Author(s): R. Suresh, D. Benitojohnson, C. Maheswari, R. Venkatnarayanan, R.Manavalan

DOI: 10.5958/0974-360X.2017.00128.7         Access: Open Access Read More

Author(s): Pankaj Kumar, Jennifer Fernandes, Abhishek Kumar

DOI: 10.5958/0974-360X.2017.00023.3         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags