Pankaj Kumar, Jennifer Fernandes, Abhishek Kumar
Pankaj Kumar*, Jennifer Fernandes, Abhishek Kumar
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka.
Volume - 10,
Issue - 1,
Year - 2017
In order to develop relatively small molecules as pharmacologically active molecules, a series of oxazolidinones having benzo thiazinen moieties and their derivatives were synthesized, and characterized by IR, 1H NMR and Mass spectral studies. Oxazolidinones were prepared from R-glycidylbutarate and Para bromo aniline. Various substituted oxazolidinones benzo thiazinen were prepared by simple reflux in the presence of acetonitrile. Treatment of these oxazolidinones benzo thiazinen deravatives with methanesulfonyl gives its sulphonates derivatives on further treatment with sodium azide and tri phenyl phosphine in acetic anhydride to give its acetamide derivatives. All the newly synthesized compounds were evaluated for antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa.
Cite this article:
Pankaj Kumar, Jennifer Fernandes, Abhishek Kumar. Synthesis and Antimicrobial Evaluation of Substituted Oxazolidinones Moieties. Research J. Pharm. and Tech. 2017; 10(1): 98-100. doi: 10.5958/0974-360X.2017.00023.3