Author(s): John Joseph, P. Perumal, Preethimol Francis

Email(s): johnjosn@yahoo.co.in

DOI: 10.5958/0974-360X.2016.00253.5   

Address: John Joseph*, P. Perumal, Preethimol Francis
Nirmala College of Pharmacy, Muvattupuzha, Kerala-686661
*Corresponding Author

Published In:   Volume - 9,      Issue - 9,     Year - 2016


ABSTRACT:
The compounds having benzimidazole heterocyclic ring system have been proven to elicit a variety of biological activities like anti-inflammatory, antispasmodic, antihistaminic, antimicrobial, antitumor analgesic and antitubercular. The presence of electron donating and electron withdrawing groups have shown different degree of magnitude in their biological activities. The present study involves the synthesis of mannich bases of 2-substituted benzimidazoles with various electron donating and electron withdrawing groups in the side chains and were screened for their potency in reducing inflammatory response. The compounds were screened by both invitro and invivo anti-inflammatory experimental models. The study revealed that the benzimidazole derivatives having the presence of both electron donating and electron withdrawing groups in their side chain showed potent anti-inflammatory effects.


Cite this article:
John Joseph, P. Perumal, Preethimol Francis. Synthesis and Anti-inflammatory Screening of Various Benzimidazole Derivatives. Research J. Pharm. and Tech 2016; 9(9):1329-1329. doi: 10.5958/0974-360X.2016.00253.5

Cite(Electronic):
John Joseph, P. Perumal, Preethimol Francis. Synthesis and Anti-inflammatory Screening of Various Benzimidazole Derivatives. Research J. Pharm. and Tech 2016; 9(9):1329-1329. doi: 10.5958/0974-360X.2016.00253.5   Available on: https://rjptonline.org/AbstractView.aspx?PID=2016-9-9-4


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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