Author(s): Hemant K. Jain, Deepak D. Deore

Email(s): hemantkjain2001@yahoo.co.in

DOI: 10.5958/0974-360X.2016.00282.1   

Address: Hemant K. Jain*, Deepak D. Deore
Department of Quality Assurance Techniques, Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune (411041), Maharashtra, India.
*Corresponding Author

Published In:   Volume - 9,      Issue - 9,     Year - 2016


ABSTRACT:
Two simple, precise, rapid, accurate and economical spectrophotometric methods have been developed for determination of Trimetazidine hydrochloride in bulk and pharmaceutical dosage form. Method A is based on measurement of absorption at 269 nm and method B involves area under curve (AUC) in wavelength range from 264 to 274 nm. The linear responses for both methods were observed in the range of 50-250 µg/ml. The percent assay value and % RSD for assay of TMZ tablet were found within acceptance criteria. The developed methods were successfully validated as per ICH guideline. Percent RSD for Intraday and Inter day precision was found to be 0.490 and 0.670 for Method A and 1.570 and 1.832 for Method B. This study indicates good precision. The accuracy of both methods was assessed by recovery studies and was found within acceptance criteria. Low value of LOD and LOQ indicate the methods are sensitive. Thus the proposed methods can be applied for routine analysis of Trimetazidine hydrochloride.


Cite this article:
Hemant K. Jain, Deepak D. Deore. Development and Validation of Spectrophotometric Method for Determination of Trimetazidine Hydrochloride in Bulk and Tablet Dosage Form. Research J. Pharm. and Tech 2016; 9(9):1457-1460. doi: 10.5958/0974-360X.2016.00282.1


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DOI: 10.5958/0974-360X 

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