Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)


Submit Article

Analytical Method Development and Validation of Alogliptin by RP-HPLC Method

Author(s): Vinyas M, Swapna Velivela, Gopi Yadav, Nikunja B Pati, VRM Gupta

Email(s): vinyasmayasa7@gmail.com

DOI: 10.5958/0974-360X.2016.00148.7   

Address: Vinyas M, Swapna Velivela, Gopi Yadav, Nikunja B Pati, VRM Gupta
Pulla Reddy Institute of Pharmacy, Annaram (V), Jinnaram (M), Medak, Telangana, India -502313
*Corresponding Author

Published In:   Volume - 9,      Issue - 7,     Year - 2016

 View HTML        View PDF

ABSTRACT:
A novel approach was used to develop and validate a rapid, specific, accurate and precise reverse phase high performance liquid chromatographic (HPLC) method for the estimation of Alogliptin phosphate mono-hydrate in pharmaceutical dosage forms. The chromatographic separation was achieved by Shiseido (250 x 4.6 mm, 5µm) column the using ratio of water and methanol as 75:25(v/v). The flow rate was 1 mL/min and the detection wavelength was 225 nm. The limit of detection (LOD) for Alogliptin phosphate monohydrate was 0.23µg/mland the limit of quantification (LOQ) for Alogliptin phosphate monohydrate was 0.78 µg/ml. This method was validated with respect to linearity, accuracy, precision, specificity and robustness. The method was also found to be stability-indicating.


Keywords:

Cite this article:
Vinyas M, Swapna Velivela, Gopi Yadav, Nikunja B Pati, VRM Gupta. Analytical Method Development and Validation of Alogliptin by RP-HPLC Method. Research J. Pharm. and Tech. 2016; 9(7):775-778. doi: 10.5958/0974-360X.2016.00148.7


Recomonded Articles:

Analytical method development and validation of ambroxol hydrochloride by UV spectroscopy and forced degradation study and detection of stability.

Author(s): M. Sumithra, P. Yuvanesh, Anamika Mistry

DOI: 10.5958/0974-360X.2016.00152.9         Access: Open Access Read More

RP-HPLC Method for Simultaneous Estimation of Albendazole and Niclosamide in Oral Suspension for Veterinary Use

Author(s): Murugan S, Upendra Janardhan CH, Niranjan Babu M

DOI: DOI: 10.5958/0974-360X.2016.00006.8         Access: Open Access Read More

Adhesive Polymers in Fabrication of Transdermal Drug delivery

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Development of a Validated Reverse Phase Liquid Chromatographic Assay-Method for determination of Tofacitinib in pure form and in Physical Admixtures

Author(s): A. S. K. Sankar, B. Datchayani, N. Balakumaran, Mohammed Rilwan, R. Subaranjani

DOI: 10.5958/0974-360X.2017.00047.6         Access: Open Access Read More

Review on: New approaches in self micro-emulsifying drug delivery system

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Taxonomical, Phytochemical and Pharmacological Reviews of Musa sapientum var. Paradisiaca.

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Analytical Method Development and Validation for Simultaneous Estimation of Montelukast and Ebastine by HPLC

Author(s): Baokar Shrikrishna, Ranpise Nisharani

DOI: 10.5958/0974-360X.2015.00001.3         Access: Open Access Read More

Spectroscopic Estimation of Tenofovir Alafenamide, an antiretroviral drug

Author(s): Pankaj Kumar, Jane Jacob, Khadjeeth Ajina, Jazeela, Fathima

DOI: 10.5958/0974-360X.2016.00101.3         Access: Open Access Read More

Method development and validation of Bronopol (Preservative) and its Stability Indicating Study by UV Spectrophotometry

Author(s): Pankaj Kapupara, Dhara Parekh, Ketan Shah

DOI: 10.5958/0974-360X.2016.00175.X         Access: Open Access Read More

A Novel Study of Machine Learning Algorithms for Classifying Health Care Data

Author(s): Meenakshi K, Safa M, Karthick T, Sivaranjani N

DOI: 10.5958/0974-360X.2017.00253.0         Access: Open Access Read More

An exhaustive review based on the formulation and evaluation methods behind the development of transdermal drug delivery systems

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

The accuracy of implant impressions: A systematic review

Author(s): Sushmitha Baskar, Dhanraj M

DOI: 10.5958/0974-360X.2017.00167.6         Access: Open Access Read More

Analytical and Bioanalytical Method for Quantification of Pure Azilsartan, Not its Salts by RP-HPLC

Author(s): Mukta D. Naykode, Durgacharan A. Bhagwat, Swapnil D. Jadhav, Harinath N. More

DOI: 10.5958/0974-360X.2017.00133.0         Access: Open Access Read More

Phytochemical Analysis and In-Vitro Antioxidant Activity of Mimosa pudica Lin., Leaves

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

A Mini-Review of Spectrophotometric and Chromatographic Analysis and Bioanalysis of Selected Recently Approved Anti-Diabetic Combinations

Author(s): Maha F. Abdel-Ghany, Miriam F. Ayad, Mariam M. Tadros

DOI: 10.5958/0974-360X.2017.00563.7         Access: Open Access Read More

Determination of Calcipotriene in Calcipotriene Cream 0.05% w/w by RP-HPLC Method Development and Validation

Author(s): Mayanka Singh, Manoj Charde, Rajesh Shukla, Rita M. Charde

DOI: Not Available         Access: Open Access Read More

An overview on the established pharmaceutical aspects associated with the development of hydrogels

Author(s): Homendra Kumar Sahu, Kamdev Sen, Raju Patel, Hulash Sahu, Deepika Sahu, Gulshan Sahu, Chandrashekhar Jain, Narayan Prasad Chandra, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00173.1         Access: Open Access Read More

Cleaning Validation Study of Amoxycillin Trihydrate

Author(s): Narendra Chotai, Vishnu Patel, Harsha Patel, Uren Patel, Rajendra Kotadiya

DOI:         Access: Open Access Read More

Analytical Method Development and Validation for the Determination of Allopurinol and Alphalipoic Acid Using Reverse Phase HPLC Method in Bulk and Tablet Dosage Form

Author(s): R. Vani, B. Vijaya Kumar, G. Krishna Mohan

DOI: 10.5958/0974-360X.2015.00038.4         Access: Open Access Read More

Simultaneous RP-HPLC Method for the Estimation of the Emtricitabine, Tenofovir Disoproxil Fumerate and Efavirenz in Tablet Dosage Forms

Author(s): N Appala Raju, Shabana Begum

DOI:         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Quick Links

Latest Issues

Popular Articles


Recent Articles



Effect of Emblica officinalis (Amla) on Monosodium Glutamate (MSG) Induced Uterine Fibroids in Wistar Rats
Regulatory requirements for Post approval changes in Japan, Canada and Malaysia
Curcumin Potentiates Therapeutic Efficacy of Metformin: A Preclinical Study in STZ-NA Induced Hyperglycemia in Wistar Rats
Synthesis and Antibacterial activity of some newer Benzimidazole derivatives
The Correction Methods of the Intestinal Microflora in Chronic Colonic Stasis by Siphon Enema and Probiotics as a Means of the Hirschsprung-associated Enterocolitis Prevention
Stability Indicating HPTLC Determination of Tadalafil Hydrochloride in Bulk Drug and Pharmaceutical Formulations
Biochemical Evaluation of Antidiabetic properties of Strychnos potatorum Seeds extract studied in High Fat Diet Fed- Low dose Streptozotocin induced experimental type 2 diabetes in Rats
In Vitro Antioxidant and Antibacterial Screening of flowers Extract from Cassia auriculata Linn.
Preparation and Evaluation of Mouth Dissolving Tablets of Loratadine by Direct Compression Method
Phytochemical assessment and Bioactivity of alcoholic extract seed of Louranthus europpaeus
Design, Development and Evaluation of Solid Form of Liquid Self-Nanoemulsifying Formulation for improving the Oral Bioavailability of Itraconazole
Optimization and Characterization of Exopolysaccharide from Marine Soil Bacteria
Development and Validation of an RP-HPLC Analytical Method for Determination of Lisinopril in Full and Split Tablets
Preparation of Silver Nanoparticles from Bael (Aegle marmelos) Leaves Extract and their Doping with Multiwalled Carbon Nanotubes for Antibacterial Utility
An effective multicomponent synthesis of 2,6-dihydro-2,6-diimino-4,8-bis (phenylamino) pyrimido [2,1-b] [1,3] thiazine-3,7-dicarbonitrile
Synthesis, Characterization and Anti-oxidant Activity of Novel Phenylhydrazine derivatives containing carbonyl group on β- carbon
Pharmacognostical Evaluation and HPTLC Analysis of Two Medicinally important Secondary Metabolites in Bauhinia variegata Leaves from Gorakhpur District in Summer Season
Formulation, Characterization of Anticancer Nanoemulsion containing Trigonella foenum-graecum L. Seed oil
Endoscopic Retrograde Cholangiopancreatography in Central Iraq: A Retrospective Single- Center Study
Biosynthesis of Gold Nanoparticles using Leaf Extract of Desmodium gangeticum and their Antioxidant Activity

Tags


About Journal

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
Read More  

Visitors

Today: 2874
Yesterday: 12852
Total: 1611191