Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)


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Analytical Method Development and Validation of Alogliptin by RP-HPLC Method

Author(s): Vinyas M, Swapna Velivela, Gopi Yadav, Nikunja B Pati, VRM Gupta

Email(s): vinyasmayasa7@gmail.com

DOI: 10.5958/0974-360X.2016.00148.7   

Address: Vinyas M, Swapna Velivela, Gopi Yadav, Nikunja B Pati, VRM Gupta
Pulla Reddy Institute of Pharmacy, Annaram (V), Jinnaram (M), Medak, Telangana, India -502313
*Corresponding Author

Published In:   Volume - 9,      Issue - 7,     Year - 2016

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ABSTRACT:
A novel approach was used to develop and validate a rapid, specific, accurate and precise reverse phase high performance liquid chromatographic (HPLC) method for the estimation of Alogliptin phosphate mono-hydrate in pharmaceutical dosage forms. The chromatographic separation was achieved by Shiseido (250 x 4.6 mm, 5µm) column the using ratio of water and methanol as 75:25(v/v). The flow rate was 1 mL/min and the detection wavelength was 225 nm. The limit of detection (LOD) for Alogliptin phosphate monohydrate was 0.23µg/mland the limit of quantification (LOQ) for Alogliptin phosphate monohydrate was 0.78 µg/ml. This method was validated with respect to linearity, accuracy, precision, specificity and robustness. The method was also found to be stability-indicating.


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Cite this article:
Vinyas M, Swapna Velivela, Gopi Yadav, Nikunja B Pati, VRM Gupta. Analytical Method Development and Validation of Alogliptin by RP-HPLC Method. Research J. Pharm. and Tech. 2016; 9(7):775-778. doi: 10.5958/0974-360X.2016.00148.7


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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