Author(s): Vinyas M, Swapna Velivela, Gopi Yadav, Nikunja B Pati, VRM Gupta

Email(s): vinyasmayasa7@gmail.com

DOI: 10.5958/0974-360X.2016.00148.7   

Address: Vinyas M, Swapna Velivela, Gopi Yadav, Nikunja B Pati, VRM Gupta
Pulla Reddy Institute of Pharmacy, Annaram (V), Jinnaram (M), Medak, Telangana, India -502313
*Corresponding Author

Published In:   Volume - 9,      Issue - 7,     Year - 2016


ABSTRACT:
A novel approach was used to develop and validate a rapid, specific, accurate and precise reverse phase high performance liquid chromatographic (HPLC) method for the estimation of Alogliptin phosphate mono-hydrate in pharmaceutical dosage forms. The chromatographic separation was achieved by Shiseido (250 x 4.6 mm, 5µm) column the using ratio of water and methanol as 75:25(v/v). The flow rate was 1 mL/min and the detection wavelength was 225 nm. The limit of detection (LOD) for Alogliptin phosphate monohydrate was 0.23µg/mland the limit of quantification (LOQ) for Alogliptin phosphate monohydrate was 0.78 µg/ml. This method was validated with respect to linearity, accuracy, precision, specificity and robustness. The method was also found to be stability-indicating.


Cite this article:
Vinyas M, Swapna Velivela, Gopi Yadav, Nikunja B Pati, VRM Gupta. Analytical Method Development and Validation of Alogliptin by RP-HPLC Method. Research J. Pharm. and Tech. 2016; 9(7):775-778. doi: 10.5958/0974-360X.2016.00148.7


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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