ABSTRACT:
The major problem associated with the antibiotic is its bitter taste when administered orally. An oral reconstitutable suspension has been one of the most favorable dosage forms for pediatric and geriatric patients that offers more palatable and stable formulation of orally administer antibiotics. Cephalexin is a beta lactam antibiotic, a good alternative of penicillin, has poor stability problem with water because of shorter half life. In the present work we have prepared a reconstitutable suspension of cephalosporin with different types of suspending agent to study the effect of suspending agents individually or in combination. The oral reconstitutable suspension was prepared by simple mixing of powdered material by geometric dilution method that was intended to be diluted at the time of administration with sufficient amount of water as directed. The suspension were prepared by using xanthan gum, HPMC, combination of both and tragacanth as suspending agent and further evaluated for rheological behavior, sedimentation properties and drug content of the formulation. The aim of the present work is to prepare an oral reconstitutable suspension of cephalosporin to improve stability and patient compliance.