Author(s): Rajan V. Rele

Email(s): drvinraj@gmail.com

DOI: 10.5958/0974-360X.2016.00095.0   

Address: Rajan V. Rele*
Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai 400016.
*Corresponding Author

Published In:   Volume - 9,      Issue - 5,     Year - 2016


ABSTRACT:
The objective of the study was to develop a simple, accurate, precise and rapid a UV spectrophotometric i.e. first order derivative method for the determination of paracetamol and guaiphenesin in combined dosage form i.e. tablets by using methanol as a solvent. The method was further validated by ICH guidelines. The proposed first order derivative method involves the measurement of absorbance of one drug at zero crossing point of other; hence wavelengths 230 nm and 263 nm were selected for the estimation of paracetamol and guaiphenesin respectively. The linearity of the proposed method was found in the concentration range of 1 to 10 µg /ml (r2= 0.9998) for paracetamol and 10 to 100 µg /ml (r2= 0.9993) for guaiphenesin respectively. The percentage mean recovery was found to be 99.955 % for paracetamol and 99.88 % for guaiphenesin respectively. The method was also statistically validated for its linearity, accuracy and precision. Both intra and inter day variations showed less percentage (%) RSD values indicating high grade of precision of this method.


Cite this article:
Rajan V. Rele. Simultaneous UV-Spectrophotometric Estimation of Paracetamol and Guaiphenesin by First Order derivative Method in Combined Dosage Form. Research J. Pharm. and Tech. 2016; 9(5): 509-512. doi: 10.5958/0974-360X.2016.00095.0


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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