Author(s): Dasari Nirmala, P.Ashok Chakradhar, M. Sudhakar

Email(s): dasarinirmala1980@gmail.com

DOI: 10.5958/0974-360X.2016.00105.0   

Address: Dasari Nirmala1*, P.Ashok Chakradhar 2, M. Sudhakar
Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally, Secunderabad -500100 Affiliated to Osmania University
*Corresponding Author

Published In:   Volume - 9,      Issue - 5,     Year - 2016


ABSTRACT:
Pitavastatin has low aqueous solubility resulting in low oral bioavailability and thus presents a challenge in formulating a suitable dosage form. To improve the aqueous solubility, a solid dispersion of Pitavastatin was prepared using mannitol as carrier by using different methods like physical mixture, melt solvent and melting method. 12 different formulations were prepared by various ratios of carrier and drug. FT-IR spectrum reveals that there is no possible interaction between drug and polymer. In vitro drug release studies shows that cumulative release of 99.68% using of melting method (mannitol 1:4) as compared to pure drug 43.1%.drug content estimation studies reveals that for all the formulation drug content within in the range of ±5% these were acceptable as per pharmacopoeial limits. As per the above results represented for formulation-4, it is obvious that Pitavastatin Mannitol (1:4) (melting method.) is proved to possess enhanced dissolution profile compare to other formulations. These results suggest that solid dispersion of pitavastatin using mannitol as carrier is a promising approach for oral delivery of Pitavastatin.


Cite this article:
Dasari Nirmala, P.Ashok Chakradhar , M. Sudhakar. Preparation and characterization of Pitavastatin solid dispersions. Research J. Pharm. and Tech. 2016; 9(5): 555-558. doi: 10.5958/0974-360X.2016.00105.0


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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