Author(s): Abhishek Kumar, Prerana Shetty, Amrutha C. L, Derin Reona Vaz, Ashlin Baby

Email(s): abhi12bunty@gmail.com

DOI: 10.5958/0974-360X.2016.00103.7   

Address: Abhishek Kumar*, Prerana Shetty, Amrutha C. L, Derin Reona Vaz, Ashlin Baby
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, NITTE University, Paneer, Deralakatte-575018, Mangalore, Karnataka.
*Corresponding Author

Published In:   Volume - 9,      Issue - 5,     Year - 2016


ABSTRACT:
A series of novel substituted 3-(2-hydroxy-6-phenylpyrimidin-4-yl)-2-H-chromen-2-one and 3-(2-mercapto-6-phenylpyrimidin-4-yl)-2-H-chromen-2-one (APY1-APY8) were synthesized upon refluxing ethanolic solution of 3-(3-phenylacryloyl)-2-H-chromen-2-one with urea/thiourea in presence of 20% KOH. The structures of the final synthesized compounds were characterized by IR, mass and 1H NMR spectra. The synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa by cup plate method. Most of the compounds exhibited promising antibacterial activity.


Cite this article:
Abhishek Kumar, Prerana Shetty, Amrutha C. L, Derin Reona Vaz, Ashlin Baby. Synthesis and Antimicrobial Evaluation of Some Novel Derivatives of Coumarin Moiety. Research J. Pharm. and Tech. 2016; 9(5): 545-548. doi: 10.5958/0974-360X.2016.00103.7


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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