ABSTRACT:
In the present work, Preliminary Phytochemical screening of Ethyl acetate, n-Butanol and Hydro-alcoholic (30:70) extracts of leaves was carried out. Acute toxicity study (ALD50) determined by Fixed dose (OCED Guideline No. 420) method of CPCSEA was adopted for toxicity studies. Hypoglycemic activity of these extract has been investigated on Normoglycemic Rats model and Oral Glucose Tolerance Test model. Result reveled that all three extract contain Flavonoids where as Alkaloids are absent. No Mortality observed during acute toxicity study at higher dose 2000 mg/kg bw so that 1/5th of higher dose i.e. 400mg/kg was used for biological evaluation. All the extracts showed significant hypoglycemic activity in Normoglycemic rats and OGTT model compare to Standard (Glibenclamide). Hydroalcoholic extract are superior to other in dose dependent manner. These findings suggest that the leaves of Bombax ceiba L have potential to lower the blood glucose level in experimental animals. Present research directs the importance of further research and development for its mechanism of action and molecular level study.