Abhishek Kumar, Jennifer Fernandes, Pankaj Kumar
Abhishek Kumar*, Jennifer Fernandes, Pankaj Kumar
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka.
Volume - 9,
Issue - 12,
Year - 2016
A series of novel substituted 1-amino-3-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)quinolin-2(1H)-one (AJP1-AJP8) have been synthesized upon reaction with 1-amino-3-cinnamoyl-quinolin-2(1H)-one using hydrazine hydrate as cyclising agent in alcohol medium. 1-amino-3-cinnamoyl-quinolin-2(1H)-one were synthesized by condensing 3-acetyl-1-amino-quinolin-2-one with different substituted benzaldehyde in presence of ethanolic KOH. The structures of the final synthesized compounds were characterized by IR, 1H NMR and mass spectra. The final synthesized compounds were screened for their antioxidant activity by DPPH radical scavenging method and in vitro cytotoxic activity against Ehrlich Ascites Carcinoma cells (EAC) by Trypan blue exclusion method.
Cite this article:
Abhishek Kumar, Jennifer Fernandes, Pankaj Kumar. Synthesis and Biological Evaluation of Some Novel Pyrazoline incorporated 2-Quinolones. Research J. Pharm. and Tech 2016; 9(12):2257-2260. doi: 10.5958/0974-360X.2016.00455.8