Author(s): Akelesh T, Venkidesh Rajagopal, Sam Johnson Udaya Chander J, Manavalan R, Venkatanarayanan R

Email(s): tmakelesh@gmail.com

DOI: 10.5958/0974-360X.2016.00440.6   

Address: Akelesh T*, Venkidesh Rajagopal, Sam Johnson Udaya Chander J, Manavalan R, Venkatanarayanan R
RVS College of Pharmaceutical Sciences, Coimbatore, Tamil Nadu, India
Corresponding Author

Published In:   Volume - 9,      Issue - 12,     Year - 2016


ABSTRACT:
The main objective of the study was to formulate floating tablets of Domperidone for sustained release of the drug. Floating tablets increase the gastric retention time, since domperidone is poorly absorbed in lower intestinal tract, the floating system will increase the bioavailabilty of the drug. The tablets were prepared by wet granulation method using Iso Propyl Alcohol. The tablets were prepared using polymers such as Hydroxy Propyl Methyl Cellulose, Methyl cellulose, and other excipients such as Sodium Carbonate, Lactose, Dicalcium Phosphate, Talc, Magnesium Stearate, etc. The polymers were found to be compatible with drug in FTIR study. Nine batches of tablets ( DF1 - DF9) were prepared using polymers at various ratios. Preformulation parameters like Bulk density, Tapped density, Carr's Compressibility index, Hausner's ratio, Angle of Repose were determined and were found to be within the limits. The tablets were evaluated for Thickness, Hardness, Friability, Weight Variation, Content uniformity. In vitro drug release study was conducted in USP Dissolution apparatus type II (Paddle type) using 0.1 N HCl as dissolution medium. It was found that the formulation DF9 released maximum drug and remained buoyant till the end of 12th hour. This formulation was subjected to stability studies for about 3 months as per ICH guidelines and was found to be stable.


Cite this article:
Akelesh T, Venkidesh Rajagopal, Sam Johnson Udaya Chander J, Manavalan R, Venkatanarayanan R. Formulation and Evaluation of Floating Effervescent Domperidone Tablets. Research J. Pharm. and Tech 2016; 9(12):2169-2179. doi: 10.5958/0974-360X.2016.00440.6


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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