Author(s): G. Muthu Bhupathi, K. Padmalatha, Akkiraju Anusha, Abdul Rameeza, Makina Geethika Sravanthi, Sunnam Praneetha.

Email(s): Email ID Not Available

DOI: 10.5958/0974-360X.2016.00377.2   

Address: G. Muthu Bhupathi1*, K. Padmalatha, Akkiraju Anusha, Abdul Rameeza, Makina Geethika Sravanthi, Sunnam Praneetha.
Department of Medicinal Chemistry, Vijaya Institute of Pharmaceutical Sciences for Women. NH-5, Enikepadu, Vijayawada - 521 108.
*Corresponding Author

Published In:   Volume - 9,      Issue - 11,     Year - 2016


ABSTRACT:
Acetanilide was the first aniline derivative serendipitously found to possess analgesic as well as antipyretic property. The literature review shows that the synthesis and characterization of acetanilide derivatives do not have the selected aldehyde derivatives. The present work was planned to synthesis acetanilide derivatives using different aromatic aldehyde derivatives like 4-dimethyl amino benzaldehyde; 3, 4, 5-trimethoxy benzaldehyde; 2-pyridine carbaldehyde; sulphonated hydrazine and PABA. Acetanilide was prepared by reacting aniline, acetic anhydride and glacial acetic acid. The produced acetanilide is the substituted with different aromatic aldehydes. Then the antimicrobial activity of synthesized acetanilide derivatives and streptomycin as standard was performed on both gram negative (E. coli, Pseudomonas aeruginosa) and gram positive (Bacillus subtilus and Bacillus cereus) organisms. The acetanilide derivatives of 3, 4- dimethyl benzaldehyde; 2- pyridine carbaldehyde; sulphonated acetanilide with PABA and sulphonated acetanilide with hydrazine compounds shows more zone of inhibition when compared streptomycin as standard. The antimicrobial effect of synthesized compounds was significant when compared with the standard drug streptomycin.


Cite this article:
G. Muthu Bhupathi, K. Padmalatha, Akkiraju Anusha, Abdul Rameeza, Makina Geethika Sravanthi, Sunnam Praneetha. Synthesis, Characterization and Antimicrobial Activity of Acetanilide Derivatives by using Aromatic Aldehydes and Sulphonamide Derivatives. Research J. Pharm. and Tech 2016; 9(11): 1846-1854. doi: 10.5958/0974-360X.2016.00377.2

Cite(Electronic):
G. Muthu Bhupathi, K. Padmalatha, Akkiraju Anusha, Abdul Rameeza, Makina Geethika Sravanthi, Sunnam Praneetha. Synthesis, Characterization and Antimicrobial Activity of Acetanilide Derivatives by using Aromatic Aldehydes and Sulphonamide Derivatives. Research J. Pharm. and Tech 2016; 9(11): 1846-1854. doi: 10.5958/0974-360X.2016.00377.2   Available on: https://rjptonline.org/AbstractView.aspx?PID=2016-9-11-6


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