Author(s): Md. Sarfaraz Alam, Pankaj Sharma

Email(s): mdalam814160@gmail.com

DOI: 10.5958/0974-360X.2016.00408.X   

Address: Md. Sarfaraz Alam1*, Pankaj Sharma1
1Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, India 313024.
*Corresponding Author

Published In:   Volume - 9,      Issue - 11,     Year - 2016


ABSTRACT:
The nanoemulsion formulation containing clobetasol propionate (CP) was prepared by spontaneous emulsification method. For the formulation of nanoemulsion Tea tree oil, Tween 80, transcutol P, and distilled water were used. Drug was incorporated in oil phase in 0.05% w/v. The lipohilic nature of drug leads to O/W nanoemulsion formulation. These were characterized by droplet size, pH, viscosity, conductivity and refractive index. Stability studies were performed as per ICH guideline for a period of 3-months. Shelf-life of nanoemulsion formulation was also determined after performing the accelerated stability testing. It was found that the droplet size, conductivity and refractive index were slightly increased while viscosity and pH, slightly decreased at refrigerator (4ºC), room temperature (25ºC) and 400C during 3 months of storage period. However, the changes in these parameters were not statistically significant (p=0.05). The degradation (%) of optimized nanoemulsion of CP were determined and the shelf-life was found to be 13.28 months at room temperature. These results indicated that the physical and chemical stability of CP were maintained in nanoemulsion formulation.


Cite this article:
Md. Sarfaraz Alam, Pankaj Sharma. Stability Study of Clobetasol Propionate Loaded Tea Tree Oil Nanoemulsion as Per ICH Guidelines. Research J. Pharm. and Tech 2016; 9(11): 1999-2004. doi: 10.5958/0974-360X.2016.00408.X

Cite(Electronic):
Md. Sarfaraz Alam, Pankaj Sharma. Stability Study of Clobetasol Propionate Loaded Tea Tree Oil Nanoemulsion as Per ICH Guidelines. Research J. Pharm. and Tech 2016; 9(11): 1999-2004. doi: 10.5958/0974-360X.2016.00408.X   Available on: https://rjptonline.org/AbstractView.aspx?PID=2016-9-11-37


Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available