Author(s): Sreekanth Nadig, Jane T. Jacob

Email(s): sreekanth30@rediffmail.com

DOI: 10.5958/0974-360X.2016.00405.4   

Address: Sreekanth Nadig *, Dr Jane T. Jacob
Department of Pharmaceutical Chemistry, Nitte Gulbishetty Institute of Pharmaceutical Sciences, Mangalore, India
*Corresponding Author

Published In:   Volume - 9,      Issue - 11,     Year - 2016


ABSTRACT:
A stability-indicating reverse phase HPLC method has been developed and validated for the simultaneous Assay estimation of Abacavir, Lamivudine, Nevirapine and Zidovudine in pharmaceutical dosage form. The chromatographic separation was achieved on a simple Inertsil ODS C18, 250 x 4.6 mm, 5 µm (Make: GL Sciences). The method employed a simple isocratic elution mode with a ternary mixture of mobile phase. The detection wavelength was set at 270 nm. The proposed method was extensively validated as per ICH guidelines. The specificity of the method was proved by performing forced degradation studies along with peak purity. This method is found to be simple, fast and economical Hence this validated method can be used in routine quality testing of individual dosage forms and combination dosage forms of Abacavir, Lamivudine, Nevirapine and Zidovudine.


Cite this article:
Sreekanth Nadig , Jane T. Jacob. A Stability Indicating RP-HPLC Assay Method for Simultaneous Estimation of Abacavir, Lamivudine, Nevirapine and Zidovudine in Pharmaceutical dosage form. Research J. Pharm. and Tech 2016; 9(11): 1985-1990. doi: 10.5958/0974-360X.2016.00405.4


Recomonded Articles:

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): A. S. K. Sankar, B. Datchayani, N. Balakumaran, Mohammed Rilwan, R. Subaranjani

DOI: 10.5958/0974-360X.2017.00047.6         Access: Open Access Read More

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Mukta D. Naykode, Durgacharan A. Bhagwat, Swapnil D. Jadhav, Harinath N. More

DOI: 10.5958/0974-360X.2017.00133.0         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Mayanka Singh, Manoj Charde, Rajesh Shukla, Rita M. Charde

DOI: Not Available         Access: Open Access Read More

Author(s): Homendra Kumar Sahu, Kamdev Sen, Raju Patel, Hulash Sahu, Deepika Sahu, Gulshan Sahu, Chandrashekhar Jain, Narayan Prasad Chandra, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00173.1         Access: Open Access Read More

Author(s): Narendra Chotai, Vishnu Patel, Harsha Patel, Uren Patel, Rajendra Kotadiya

DOI:         Access: Open Access Read More

Author(s): N. Chandarsekaran, M. Balamurugan

DOI: Not Available         Access: Open Access Read More

Author(s): Vikram Kumar Sahu, Amit Mishra, Nitin Sharma, Pratap Kumar Sahu, Shubhini A. Saraf

DOI: 10.5958/0974-360X.2017.00048.8         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags