Author(s): Hemant K. Jain, Niraj K. Muley, Neha N. Deshpande

Email(s): hemantkjain2001@yahoo.co.in

DOI: 10.5958/0974-360X.2016.00341.3   

Address: Hemant K. Jain*, Niraj K. Muley, Neha N. Deshpande
Department of Quality Assurance Techniques, STES’s Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune-411041, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 9,      Issue - 10,     Year - 2016


ABSTRACT:
Two simple, precise, rapid, accurate and economical spectrophotometric methods have been developed for determination of Nadolol in bulk and tablets. First method was based on measurement of area under curve for spectrum in a wavelength range between 267.6 – 274.6 nm and second method involved first order derivative spectrophotometry at a wavelength 281.6 nm. These methods have been validated as per ICH guidelines. The linearity for first method was found in the concentration range of 80-180 µg/ml and the value of correlation coefficient (R2) was found to be 0.9969. Linearity of second method was found in 80-180 µg/ml concentration and the value of correlation coefficient (R2) was found to be 0.9988. The percent assay values obtained by both methods were found within acceptance limits. Percent R.S.D for precision study by both methods were also found to be satisfactory indicated reproducibility of the methods. The values of % R.S.D were found to be satisfactory suggested both methods were precise. The accuracy of both methods was assessed by recovery studies and % recovery values were found within acceptance criteria. Thus both methods can be applied for routine analysis of Nadolol.


Cite this article:
Hemant K. Jain, Niraj K. Muley, Neha N. Deshpande. Estimation of Nadolol in Bulk and Tablets by Area under Curve and First Order Derivative Spectrophotometry. Research J. Pharm. and Tech 2016; 9(10):1694-1698. doi: 10.5958/0974-360X.2016.00341.3


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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