Author(s): Smita S. Aher, Vaishali D. Sangale, Ravindra B. Saudagr

Email(s): smitarohokale@yahoo.com

DOI: Not Available

Address: Smita S. Aher1*, Vaishali D. Sangale2 ,Ravindra B. Saudagr1
1Department of Pharmaceutical Chemistry, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213. Maharashtra, India
1Department of Quality Assurance Technique, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213. Maharashtra, India
*Corresponding Author

Published In:   Volume - 9,      Issue - 10,     Year - 2016


ABSTRACT:
The objective of this research was to formulate fast dissolving sublingual film of Hydralazine hydrochloride for rapid action. Hydralazine hydrochloride is a direct acting smooth muscle relaxant used to treat hypertension. It belongs to the hydrazinophthalazine class of drugs. Solvent casting method was adapted to prepare the sublingual films by using a 32 full factorial design. of their components or with individual components 1. FT-IR and Dissolution studies revealed that there was no physico-chemical interaction between Hydralazine hydrochloride and other polymer. All formulations are evaluated for tensile strength, weight variations, moisture content, mucoadhesion strength, in-vitro disintegration study, in-vitro dissolution study, uniformity of drug content, surface pH, % elongation break ,folding endurance. F6 batch contain Hydralazine hydrochloride (Drug), PVA, PVPK-30 and PEG-400. F9 batch was the optimized batch since it showed of Disintegration time (59 sec), surface PH (6.80) and %Drug release (98.55%).


Cite this article:
Smita S. Aher, Vaishali D. Sangale ,Ravindra B. Saudagr. Formulation and evaluation of sublingual film of Hydralazine Hydrochloride. Research J. Pharm. and Tech 2016; 9(10):1681-1690.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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