Author(s): Abdul Hasan Sathali. A, Jeya Chandra Prakash. S.K.

Email(s): ahsathali@gmail.com

DOI: 10.5958/0974-360X.2015.00235.8   

Address: Dr. Abdul Hasan Sathali. A*, Jeya Chandra Prakash. S.K.
The Principal and HOD, Department of Pharmaceutics, College of Pharmacy, Madurai Medical College, Madurai- 625 020, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 8,      Issue - 9,     Year - 2015


ABSTRACT:
Amisulpride is an antipsychotic drug which belongs to BCS type II classification. The present study aims to develop nanocrystals of amisulpride in order to enhance solubility and dissolution rate by decreasing particle size of drug. The amisulpride nanocrystals with small and uniform particle size were successfully prepared by emulsion solvent diffusion method is based on the high pressure homogenization technique using ß-cyclodextrin, sodium lauryl sulphate, hydroxy propyl methyl cellulose E15 and polyvinyl alcohol as stabilizers at different concentrations. The compatability studies was done by infrared spectroscopy and differential scanning calorimetry showed that no interaction between the drug and stabilizers. The amisulpride nanocrystals were evaluated for drug content, invitro dissolution study, SEM , X-ray powder diffraction, particle size distribution, zeta potential and solubility studies. The X-ray powder diffraction (XRPD) confirmed that there was no change in the crystalline state by this size reduction process. The presence of stabilizers made the nanocrystal formulations more stable. The solubility and in vitro dissolution studies suggested that the nanocrystal formulations can improve the bioavailability of the amisulpride by improving its solubility and dissolution rate when compared to pure drug. It was showed that BCD 1.8% concentration gives better drug release profile and enhances the solubility. The amisulpride nanocrystal tablets were successfully prepared from the best formulation by direct compression method. Precompression and post compression evaluation studies are also performed. Amisulpride nanocrystal tablet showed better drug release profile when compared to marketed and amisulpride tablet.


Cite this article:
Abdul Hasan Sathali. A, Jeya Chandra Prakash. S.K. Formulation and Evaluation of Amisulpride Nanocrystal Tablets. Research J. Pharm. and Tech. 8(9): Sept., 2015; Page 1294-1306. doi: 10.5958/0974-360X.2015.00235.8


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DOI: 10.5958/0974-360X 

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